原创力文档viral mimicry of cdc2cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress病毒模仿cdc2cyclin-dependent激酶1介导核板的破坏在人类巨细胞病毒核出口.pdfVIP
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viral mimicry of cdc2cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress病毒模仿cdc2cyclin-dependent激酶1介导核板的破坏在人类巨细胞病毒核出口
Viral Mimicry of Cdc2/Cyclin-Dependent Kinase 1
Mediates Disruption of Nuclear Lamina during Human
Cytomegalovirus Nuclear Egress
Sofia Hamirally1.¤a, Jeremy P. Kamil1., Yasmine M. Ndassa-Colday 1,2, Alison J. Lin1,3, Wan Jin Jahng1¤b,
1¤c 1¤d 1 4¤e 3
Moon-Chang Baek , Sarah Noton , Laurie A. Silva , Martha Simpson-Holley , David M. Knipe ,
1,5 1,2 1
David E. Golan , Jarrod A. Marto , Donald M. Coen *
1 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America, 2 Dana-Farber Cancer
Institute, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School,
Boston, Massachusetts, United States of America, 4 Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, United States of
America, 5 Hematology Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
Abstract
The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their passage from the nucleus to the
cytoplasm (nuclear egress). We found that the human cytomegalovirus (HCMV)-encoded protein kinase UL97, which is
required for efficient nuclear egress, phosphorylates the nuclear lamina component lamin A/C in vitro on sites targeted by
Cdc2/cyclin-dependent kinase 1, the enzyme that is responsible for breaking down the nuclear lamina during mitosis.
Quantitative mass spectrometry analyses, comparing lamin A/C isolated from cells infect
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