原创力文档virus-receptor mediated transduction of dendritic cells by lentiviruses enveloped with glycoproteins derived from semliki forest virus病毒受体介导转导的树突细胞通过慢病毒包膜糖蛋白源自semliki森林病毒.pdfVIP
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virus-receptor mediated transduction of dendritic cells by lentiviruses enveloped with glycoproteins derived from semliki forest virus病毒受体介导转导的树突细胞通过慢病毒包膜糖蛋白源自semliki森林病毒
Virus-Receptor Mediated Transduction of Dendritic Cells
by Lentiviruses Enveloped with Glycoproteins Derived
from Semliki Forest Virus
1 1 1 1 1,2,3
Steven Froelich , April Tai , Katie Kennedy , Adnan Zubair , Pin Wang *
1 Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California, United States of America,
2 Department of Biomedical Engineering, University of Southern California, Los Angeles, California, United States of America, 3 Department of Pharmacology and
Pharmaceutical Sciences, University of Southern California, Los Angeles, California, United States of America
Abstract
Lentiviruses have recently attracted considerable interest for their potential as a genetic modification tool for dendritic cells
(DCs). In this study, we explore the ability of lentiviruses enveloped with alphaviral envelope glycoproteins derived from
Semliki Forest virus (SFV) to mediate transduction of DCs. We found that SFV glycoprotein (SFV-G)-pseudotyped lentiviruses
use C-type lectins (DC-SIGN and L-SIGN) as attachment factors for transduction of DCs. Importantly, SFV-G pseudotypes
appear to have enhanced transduction towards C-type lectin-expressing cells when produced under conditions limiting
glycosylation to simple high-mannose, N-linked glycans. These results, in addition to the natural DC tropism of SFV-G, offer
evidence to support the use of SFV-G-bearing lentiviruses to genetically modify DCs for the study of DC biology and DC-
based immunotherapy.
Citation: Froelich S, Tai A, Kennedy K, Zubair A, Wang P (2011) Virus-Receptor Mediated Transduction of Dendritic Cells by Lentiviruses Enveloped with
Glycoproteins Deri
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