原创力文档virus-heat shock protein interaction and a novel axis for innate antiviral immunityvirus-heat休克蛋白相互作用和天生的抗病毒免疫的新轴.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
virus-heat shock protein interaction and a novel axis for innate antiviral immunityvirus-heat休克蛋白相互作用和天生的抗病毒免疫的新轴
Cells 2012, 1, 646-666; doi:10.3390/cells1030646
OPEN ACCESS
cells
ISSN 2073-4409
/ journal / cells
Review
Virus-Heat Shock Protein Interaction and a Novel Axis for
Innate Antiviral Immunity
Mi Young Kim * and Michael Oglesbee
Department of Veterinary Biosciences, The Ohio State University, 1925 Coffey Road, Columbus,
OH 43210, USA; E-Mail: Michael.Oglesbee@
* Author to whom correspondence should be addressed; E-Mail: kim.2612@;
Tel.:+1-614-298-4211; Fax: +1-614-292-6473.
Received: 1 August 2012; in revised form: 24 August 2012 / Accepted: 27 August 2012 /
Published: 11 September 2012
Abstract: Virus infections induce heat shock proteins that in turn enhance virus gene
expression, a phenomenon that is particularly well characterized for the major inducible
70 kDa heat shock protein (hsp70). However, hsp70 is also readily induced by fever, a
phylogenetically conserved response to microbial infections, and when released from cells,
hsp70 can stimulate innate immune responses through toll like receptors 2 and 4 (TLR2 and 4).
This review examines how the virus-hsp70 relationship can lead to host protective innate
antiviral immunity, and the importance of hsp70 dependent stimulation of virus gene
expression in this host response. Beginning with the well-characterized measles
virus-hsp70 relationship and the mouse model of neuronal infection in brain, we examine
dat
您可能关注的文档
- using grizzly bears to assess harvest-ecosystem tradeoffs in salmon fisheries使用灰熊在鲑鱼渔业评估harvest-ecosystem权衡.pdf
- using goal- and grip-related information for understanding the correctness of other’s actions an erp study使用目标u2014u2014和grip-related信息对于理解其他erp的行动研究的正确性.pdf
- using hydrophilic ionic liquid, [bmim]bf4 – ethylene glycol system as a novel media for the rapid synthesis of copper nanoparticles使用亲水离子液体[bmim]bf4 -乙二醇系统作为一种新型媒体的快速合成铜纳米粒子.pdf
- using hierarchical clustering of secreted protein families to classify and rank candidate effectors of rust fungi使用层次聚类分泌蛋白质的家庭分类和等级候选人效应器锈真菌.pdf
- using knowledge fusion to analyze avian influenza h5n1 in east and southeast asia使用知识融合分析禽流感h5n1病毒在东亚和东南亚.pdf
- using information theory to study efficiency and capacity of computers and similar devices利用信息理论来研究电脑和类似设备的效率和能力.pdf
- using morphological, molecular and climatic data to delimitate yews along the hindu kush-himalaya and adjacent regions使用形态学、分子和气候数据清楚地说明紫杉印度教kush-himalaya和邻近地区.pdf
- using molecular-assisted alpha taxonomy to better understand red algal biodiversity in bermuda使用molecular-assistedα分类更好地理解红藻生物多样性在百慕大.pdf
- using gis in ecological management green assessment of the impacts of petroleum activities in the state of texas使用gis的生态管理绿色评估的影响在德克萨斯州石油活动.pdf
- using multiple phenotype assays and epistasis testing to enhance the reliability of rnai screening and identify regulators of muscle protein degradation使用多个表型分析和上位测试提高rnai的可靠性筛选和识别监管者肌肉蛋白质的降解.pdf
- viscosity in modified gravity粘度在修改引力.pdf
- visfatin impairs endothelium-dependent relaxation in rat and human mesenteric microvessels through nicotinamide phosphoribosyltransferase activityvisfatin损害endothelium-dependent放松在老鼠和人类肠系膜微血管通过烟酰胺phosphoribosyltransferase活动.pdf
- visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by nfκb and jnk in human abdominal subcutaneous adipocytesvisfatin受罗格列酮在2型糖尿病和受到nfκb和物在人类腹部皮下脂肪细胞.pdf
- visiting sick people is it really detrimental to our health看望生病的人真的是对我们的健康有害.pdf
- visual advantage in deaf adults linked to retinal changes在成年聋人与视网膜视觉优势的变化.pdf
- virus-infection or 5′ppp-rna activates antiviral signal through redistribution of ips-1 mediated by mfn1病毒感染或5u2032ppp-rna激活抗病毒信号通过mfn1 ips-1介导的重新分配.pdf
- visual laterality of calf–mother interactions in wild whales视觉一侧calf-mother交互在野生鲸鱼.pdf
- visual lateralization in wild striped dolphins (stenella coeruleoalba) in response to stimuli with different degrees of familiarity视觉偏侧性野生条纹海豚(stenella coeruleoalba)在回应刺激与不同程度的熟悉.pdf
- visual coding in locust photoreceptors蝗虫的视觉编码光感受器.pdf
- visual feature integration indicated by phase-locked frontal-parietal eeg signals视觉功能集成锁相frontal-parietal eeg信号所示.pdf
文档评论（0）