原创力文档visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by nfκb and jnk in human abdominal subcutaneous adipocytesvisfatin受罗格列酮在2型糖尿病和受到nfκb和物在人类腹部皮下脂肪细胞.pdfVIP
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visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by nfκb and jnk in human abdominal subcutaneous adipocytesvisfatin受罗格列酮在2型糖尿病和受到nfκb和物在人类腹部皮下脂肪细胞
Visfatin Is Regulated by Rosiglitazone in Type 2 Diabetes
Mellitus and Influenced by NFkB and JNK in Human
Abdominal Subcutaneous Adipocytes
1. 1. 1 2 1
Kirsty C. McGee , Alison L. Harte , Nancy F. da Silva , Nasser Al-Daghri , Steven J. Creely , Christine M.
1 1 3 4 4 1
Kusminski , Gyanendra Tripathi , Paul L. Levick , Manish Khanolkar , Marc Evans , Madhu V. Chittari ,
5 1 1
Vinod Patel , Sudhesh Kumar , Philip G. McTernan *
1 Unit for Diabetes Metabolism, Clinical Sciences Research Institute, UHCW Trust, Walsgrave, Coventry, United Kingdom, 2 Biomarkers Research Program, Biochemistry
Department, College of Science, King Saud University, Riyadh, Saudi Arabia, 3 Priory Hospital, BMI, Edgbaston, Birmingham, United Kingdom, 4 Heart Research Institute,
Cardiff University, Wales, United Kingdom, 5 Diabetes Centre, George Eliot Hospital NHS Trust, Nuneaton, United Kingdom
Abstract
Visfatin has been proposed as an insulin-mimicking adipocytokine, predominantly secreted from adipose tissue and
correlated with obesity. However, recent studies suggest visfatin may act as a proinflammatory cytokine. Our studies sought
to determine the significance of this adipocytokine and its potential role in the pathogenesis of T2DM. Firstly, we examined
the effects of diabetic status on circulating visfatin levels, and several other adipocytokines, demonstrating that diabetic
status increased visfatin*, TNF-a*** and IL-6*** compared with non-diabetic subjects (*p,0.05, **p,0.01, ***p,0.001,
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