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using networks to understand medical data the case of class iii malocclusions用网络来了解医疗数据第三类咬合不正的情况.pdf

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using networks to understand medical data the case of class iii malocclusions用网络来了解医疗数据第三类咬合不正的情况

Using Networks To Understand Medical Data: The Case of Class III Malocclusions 1,2 1,3 1 1,2,4 5,6,7,8 Antonio Scala *, Pietro Auconi , Marco Scazzocchio , Guido Caldarelli , James A. McNamara , Lorenzo Franchi5,9 1 Istituto dei Sistemi Complessi Udr ‘‘La Sapienza’’, Roma, Italy, 2 London Institute of Mathematical Sciences, London, United Kingdom, 3 Private Practice of Orthodontics, Rome, Italy, 4 NATWORKS Unit for the Study of Natural Networks, IMT Lucca Institute for Advanced Studies, Lucca, Italy, 5 Department of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of Michigan, Ann Arbor, Michigan, United States of America, 6 Department of Cell and Developmental Biology, School of Medicine, The University of Michigan, Ann Arbor, Michigan, United States of America, 7 Center for Human Growth and Development, The University of Michigan, Ann Arbor, Michigan, United States of America, 8 Private Practice of Orthodontics, Ann Arbor, Michigan, United States of America, 9 Department of Orthodontics, The University of Florence, Florence, Italy Abstract A system of elements that interact or regulate each other can be represented by a mathematical object called a network. While network analysis has been successfully applied to high-throughput biological systems, less has been done regarding their application in more applied fields of medicine; here we show an application based on standard medical diagnostic data. We apply network analysis to Class III malocclusion, one of the most difficult to understand and treat orofacial anomaly. We hypothesize that different interactions of the skeletal components can contr