原创力文档using poison center exposure calls to predict methadone poisoning deaths使用接触毒物中心调用预测美沙酮中毒死亡.pdfVIP
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using poison center exposure calls to predict methadone poisoning deaths使用接触毒物中心调用预测美沙酮中毒死亡
Using Poison Center Exposure Calls to Predict
Methadone Poisoning Deaths
1 2 1 2,3
Nabarun Dasgupta *, Jonathan Davis , Michele Jonsson Funk , Richard Dart
1 Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, United States of America, 2 Rocky
Mountain Poison and Drug Center, Denver Health, Denver, Colorado, United States of America, 3 School of Medicine, University of Colorado, Denver, Colorado, United
States of America
Abstract
Purpose: There are more drug overdose deaths in the Untied States than motor vehicle fatalities. Yet the US vital statistics
reporting system is of limited value because the data are delayed by four years. Poison centers report data within an hour of
the event, but previous studies suggested a small proportion of poisoning deaths are reported to poison centers (PC). In an
era of improved electronic surveillance capabilities, exposure calls to PCs may be an alternate indicator of trends in
overdose mortality.
Methods: We used PC call counts for methadone that were reported to the Researched Abuse, Diversion and Addiction-
Related Surveillance (RADARSH) System in 2006 and 2007. US death certificate data were used to identify deaths due to
methadone. Linear regression was used to quantify the relationship of deaths and poison center calls.
Results: Compared to decedents, poison center callers tended to be younger, more often female, at home and less likely to
require medical attention. A strong association was found with PC calls and methadone mortality (b = 0.88, se = 0.42, t = 9.5,
df = 1, p,0.0001, R2 = 0.77). These findings were robust to large changes in a sensitivity analysis assessing the impact of
underreporting of methadone overdos
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