using physiologically-based pharmacokinetic models to incorporate chemical and non-chemical stressors into cumulative risk assessment a case study of pesticide exposures使用有着生理基础的药代动力学模型将化学和非化学压力的累积风险评估案例研究农药暴露.pdfVIP

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using physiologically-based pharmacokinetic models to incorporate chemical and non-chemical stressors into cumulative risk assessment a case study of pesticide exposures使用有着生理基础的药代动力学模型将化学和非化学压力的累积风险评估案例研究农药暴露.pdf

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using physiologically-based pharmacokinetic models to incorporate chemical and non-chemical stressors into cumulative risk assessment a case study of pesticide exposures使用有着生理基础的药代动力学模型将化学和非化学压力的累积风险评估案例研究农药暴露

Int. J. Environ. Res. Public Health 2012, 9, 1971-1983; doi:10.3390/ijerph9051971 OPEN ACCESS International Journal of Environmental Research and Public Health ISSN 1660-4601 /journal/ijerph Article Using Physiologically-Based Pharmacokinetic Models to Incorporate Chemical and Non-Chemical Stressors into Cumulative Risk Assessment: A Case Study of Pesticide Exposures Susan C. Wason 1,*, Thomas J. Smith 1, Melissa J. Perry 1,2 and Jonathan I. Levy 1,3 1 Department of Environmental Health, Harvard School of Public Health, 401 Park Drive West, Boston, MA 02215, USA; E-Mails: tsmith@ (T.J.S.); mperry@ (M.J.P.); jonlevy@ (J.I.L.) 2 Department of Environmental and Occupational Health, School of Public Health and Health Service, George Washington University, 2300 Eye St. NW, Washington, DC 20037, USA 3 Department of Environmental Health, Boston University School of Public Health, 715 Albany St., Boston, MA 02118, USA * Author to whom correspondence should be addressed; E-Mail: swason@; Tel.: +1-617-384-8829; Fax: +1-617-384-8819. Received: 26 March 2012 / Accepted: 11 April 2012 / Published: 22 May 2012 Abstract: Cumulative risk assessment has been proposed as an approach to evaluate the health risks associated with simultaneous exposure to multiple chemical and non-chemical stressors. Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models can allow