原创力文档virus-infection or 5′ppp-rna activates antiviral signal through redistribution of ips-1 mediated by mfn1病毒感染或5u2032ppp-rna激活抗病毒信号通过mfn1 ips-1介导的重新分配.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
virus-infection or 5′ppp-rna activates antiviral signal through redistribution of ips-1 mediated by mfn1病毒感染或5u2032ppp-rna激活抗病毒信号通过mfn1 ips-1介导的重新分配
Virus-Infection or 5 9ppp-RNA Activates Antiviral Signal
through Redistribution of IPS-1 Mediated by MFN1
1,2,3 1 1,2 1,2 1
Kazuhide Onoguchi , Koji Onomoto , Shiori Takamatsu , Michihiko Jogi , Azumi Takemura , Shiho
1 4 3 5,6 1,2
Morimoto , Ilkka Julkunen , Hideo Namiki , Mitsutoshi Yoneyama , Takashi Fujita *
1 Department of Molecular Genetics, Institute for Virus Research, Kyoto University, Kyoto, Japan, 2 Graduate School of Biostudies, Kyoto University, Yoshida-Konoe Sakyo,
Kyoto, Japan, 3 Graduate School of Science and Engineering, Waseda University, Tokyo, Japan, 4 Department of Vaccination and Immune Protection, National Institute for
Health and Welfare, Helsinki, Finland, 5 Division of Molecular Immunology, Medical Mycology Research Center, Chiba University, Chuo-ku, Chiba, Japan, 6 PRESTO, Japan
Science and Technology Agency, Saitama, Japan
Abstract
In virus-infected cells, RIG-I-like receptor (RLR) recognizes cytoplasmic viral RNA and triggers innate immune responses
including production of type I and III interferon (IFN) and the subsequent expression of IFN-inducible genes. Interferon-b
promoter stimulator 1 (IPS-1, also known as MAVS, VISA and Cardif) is a downstream molecule of RLR and is expressed on
the outer membrane of mitochondria. While it is known that the location of IPS-1 is essential to its function, its underlying
mechanism is unknown. Our aim in this study was to delineate the function of mitochondria so as to identify more precisely
its role in innate immunity. In doing so we discovered that viral infecti
您可能关注的文档
- using hiv transmission networks to investigate community effects in hiv prevention trials使用艾滋病毒传播网络调查社区影响艾滋病毒预防试验.pdf
- using gis mapping of the extent of nearshore rocky reefs to estimate the abundance and reproductive output of important fishery species使用gis映射近岸岩石暗礁的程度估计重要渔业物种的丰度和繁殖输出.pdf
- using physiologically-based pharmacokinetic models to incorporate chemical and non-chemical stressors into cumulative risk assessment a case study of pesticide exposures使用有着生理基础的药代动力学模型将化学和非化学压力的累积风险评估案例研究农药暴露.pdf
- using poison center exposure calls to predict methadone poisoning deaths使用接触毒物中心调用预测美沙酮中毒死亡.pdf
- using online tools to assess public responses to climate change mitigation policies in japan使用在线工具来评估在日本公众应对气候变化缓解政策.pdf
- using population genetic theory and dna sequences for species detection and identification in asexual organisms使用人口遗传理论和dna序列的物种在无性生物探测和识别.pdf
- using plant functional traits to explain diversity–productivity relationships使用植物功能性状来解释diversity-productivity关系.pdf
- using quantum computers for quantum simulation使用量子模拟量子计算机.pdf
- using remote sensing and gis in the analysis of ecosystem decline along the river niger basin the case of mali and niger利用遥感和gis分析沿着尼日尔河流域生态系统衰退的马里和尼日尔.pdf
- using ribosomal protein genes as reference a tale of caution使用核糖体蛋白基因作为引用一个谨慎的故事.pdf
- visual laterality of calf–mother interactions in wild whales视觉一侧calf-mother交互在野生鲸鱼.pdf
- visual lateralization in wild striped dolphins (stenella coeruleoalba) in response to stimuli with different degrees of familiarity视觉偏侧性野生条纹海豚(stenella coeruleoalba)在回应刺激与不同程度的熟悉.pdf
- visual coding in locust photoreceptors蝗虫的视觉编码光感受器.pdf
- visual feature integration indicated by phase-locked frontal-parietal eeg signals视觉功能集成锁相frontal-parietal eeg信号所示.pdf
- visual learning in multiple-object tracking视觉学习多对象跟踪.pdf
- visible light-induced degradation of methylene blue in the presence of photocatalytic zns and cds nanoparticles可见光照造成的降解亚甲基蓝的光催化的硫化锌和cd纳米粒子的存在.pdf
- visions, scenarios and action plans towards next generation tanzania power system愿景,场景和行动计划向下一代坦桑尼亚电力系统.pdf
- visual recognition of age class and preference for infantile features implications for species-specific vs universal cognitive traits in primates视觉识别的类和偏爱幼稚的特性对灵长类动物特有的和普遍的认知特征的影响.pdf
- visual information alone changes behavior and physiology during social interactions in a cichlid fish (astatotilapia burtoni)视觉信息仅在社会交往行为和生理变化在一个鲷鱼(astatotilapia burtoni).pdf
- visual responses in mice lacking critical components of all known retinal phototransduction cascades视觉反应老鼠缺乏关键部件的所有已知的视网膜phototransduction瀑布.pdf
文档评论（0）