visfatin impairs endothelium-dependent relaxation in rat and human mesenteric microvessels through nicotinamide phosphoribosyltransferase activityvisfatin损害endothelium-dependent放松在老鼠和人类肠系膜微血管通过烟酰胺phosphoribosyltransferase活动.pdfVIP
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visfatin impairs endothelium-dependent relaxation in rat and human mesenteric microvessels through nicotinamide phosphoribosyltransferase activityvisfatin损害endothelium-dependent放松在老鼠和人类肠系膜微血管通过烟酰胺phosphoribosyltransferase活动
Visfatin Impairs Endothelium-Dependent Relaxation in
Rat and Human Mesenteric Microvessels through
Nicotinamide Phosphoribosyltransferase Activity
1. 1,6. 2 1,6 1,6
Susana Vallejo , Tania Romacho , Javier Angulo , Laura A. Villalobos , Elena Cercas , Alejandra
1,6 3 4,5,6 ´ 1,6 ´ ´ 1,6
Leivas , Elena Bermejo , Raffaele Carraro , Carlos F. Sanchez-Ferrer , Concepcion Peiro *
´ ´ ´ ´ ´
1 Departamento de Farmacologıa, Universidad Autonoma de Madrid, Madrid, Spain, 2 Departamento de Histologıa, Instituto Ramon y Cajal de Investigacion Sanitaria
´ ´
(IRYCIS), Madrid, Spain, 3 Servicio de Cirugıa General y Digestiva, Hospital de la Princesa, Madrid, Spain, 4 Unidad de Obesidad, Servicio de Endocrinologıa, Hospital de la
´ ´
Princesa, Madrid, Spain, 5 Departamento de Medicina, Universidad Autonoma de Madrid, Madrid, Spain, 6 Instituto de Investigacion Sanitaria del Hospital de la Princesa,
Madrid, Spain
Abstract
Visfatin, also known as extracellular pre–B-cell colony–enhancing factor (PBEF) and nicotinamide phosphoribosyltransferase
(Nampt), is an adipocytokine whose circulating levels are enhanced in metabolic
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