using an improved phagocytosis assay to evaluate the effect of hiv on specific antibodies to pregnancy-associated malaria使用一种改进的吞噬作用分析来评估艾滋病的影响在特定的抗体乳疟疾.pdfVIP

Using an Improved Phagocytosis Assay to Evaluate the Effect of HIV on Specific Antibodies to Pregnancy- Associated Malaria ´ 1,2 1 3 3 4,5 Ricardo Ataıde , Wina Hasang , Danny W. Wilson , James G. Beeson , Victor Mwapasa , Malcolm E. 4,6 7 1 Molyneux , Steven R. Meshnick , Stephen J. Rogerson * 1 Department of Medicine, University of Melbourne, Post Office Royal Melbourne Hospital, Melbourne, Victoria, Australia, 2 GABBA, Graduate Program in Areas of Basic and Applied Biology, Universidade do Porto, Porto, Portugal, 3 Infection and Immunity Division, the Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia, 4 Malawi-Liverpool-Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi, 5 Department of Community Health, University of Medicine, University of Malawi, Blantyre, Malawi, 6 School of Tropical Medicine, University of Liverpool, Liverpool, United Kingdom, 7 Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, United States of America Abstract Background: Pregnant women residing in malaria endemic areas are highly susceptible to Plasmodium falciparum malaria, particularly during their first pregnancy, resulting in low birth weight babies and maternal anaemia. This susceptibility is associated with placental sequestration of parasitised red blood cells expressing pregnancy-specific variant surface antigens. Acquisition of antibodies against these variant surface antigens may protect women and their offspring. Fun