原创力文档virion assembly factories in the nucleus of polyomavirus-infected cells病毒粒子的组装工厂polyomavirus-infected细胞的细胞核.pdfVIP
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virion assembly factories in the nucleus of polyomavirus-infected cells病毒粒子的组装工厂polyomavirus-infected细胞的细胞核
Virion Assembly Factories in the Nucleus of
Polyomavirus-Infected Cells
1,2. 1. 1,2 3
Kimberly D. Erickson , Cedric Bouchet-Marquis , Katie Heiser , Eva Szomolanyi-Tsuda ,
3 3 1 1,2
Rabinarayan Mishra , Benjamin Lamothe , Andreas Hoenger , Robert L. Garcea *
1 Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado, United States of America, 2 The Biofrontiers Institute,
University of Colorado, Boulder, Colorado, United States of America, 3 Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts,
United States of America
Abstract
Most DNA viruses replicate in the cell nucleus, although the specific sites of virion assembly are as yet poorly defined.
Electron microscopy on freeze-substituted, plastic-embedded sections of murine polyomavirus (PyV)-infected 3T3 mouse
fibroblasts or mouse embryonic fibroblasts (MEFs) revealed tubular structures in the nucleus adjacent to clusters of
assembled virions, with virions apparently ‘‘shed’’ or ‘‘budding’’ from their ends. Promyelocytic leukemia nuclear bodies
(PML-NBs) have been suggested as possible sites for viral replication of polyomaviruses (BKV and SV40), herpes simplex virus
(HSV), and adenovirus (Ad). Immunohistochemistry and FISH demonstrated co-localization of the viral T-antigen (Tag), PyV
DNA, and the host DNA repair protein MRE11, adjacent to the PML-NBs. In PML2/ 2 MEFs the co-localization of MRE11, Tag,
and PyV DNA remained
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