原创力文档virologic and immunologic evidence supporting an association between hhv-6 and hashimotos thyroiditis病毒学和免疫证据支持hhv - 6之间的关联和桥本氏甲状腺炎.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
virologic and immunologic evidence supporting an association between hhv-6 and hashimotos thyroiditis病毒学和免疫证据支持hhv - 6之间的关联和桥本氏甲状腺炎
Virologic and Immunologic Evidence Supporting an
Association between HHV-6 and Hashimoto’s Thyroiditis
1 2 1 1 3
Elisabetta Caselli *, Maria Chiara Zatelli , Roberta Rizzo , Sabrina Benedetti , Debora Martorelli ,
2 1 2 1 3
Giorgio Trasforini , Enzo Cassai , Ettore C. degli Uberti , Dario Di Luca , Riccardo Dolcetti
1 Section of Microbiology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy, 2 Section of Endocrinology, Department of
Biomedical Sciences and Advanced Therapies and LTTA, University of Ferrara, Ferrara, Italy, 3 Cancer Bio-Immunotherapy Unit, CRO – IRCCS, National Cancer Institute,
Aviano, Italy
Abstract
Hashimoto’s thyroiditis (HT) is the most common of all thyroid diseases and is characterized by abundant lymphocyte
infiltrate and thyroid impairment, caused by various cell- and antibody-mediated immune processes. Viral infections have
been suggested as possible environmental triggers, but conclusive data are not available. We analyzed the presence and
transcriptional state of human herpesvirus 6 (HHV-6) in thyroid fine needle aspirates (FNA) and peripheral blood
mononuclear cells (PBMCs) from 34 HT patients and 28 controls, showing that HHV-6 DNA prevalence (82% vs. 10%,
p#0.001) and viral load were significantly increased in FNA from HT patients, and thyrocytes from HT FNA displayed a 100-
fold higher HHV-6 DNA load compared to infiltrating lymphocytes. In addition, while HHV-6 was strictly latent in positive
samples from controls, a low grade acute infection was detected in HT samples
您可能关注的文档
- use of temporary implantable biomaterials to reduce leg pain and back pain in patients with sciatica and lumbar disc herniation使用临时植入生物材料以减少腿部疼痛和背部疼痛患者的坐骨神经痛和腰椎间盘突出症.pdf
- use of the internal transcribed spacer (its) regions to examine symbiont divergence and as a diagnostic tool for sodalis-related bacteria使用内部转录间隔区(its)地区检查共生者散度和作为sodalis-related细菌的诊断工具.pdf
- use of the mlpa assay in the molecular diagnosis of gene copy number alterations in human genetic diseases使用mlpa分子诊断试验的基因拷贝数改变人类遗传疾病.pdf
- use-exposure relationships of pesticides for aquatic risk assessment用曝光农药对水生生物风险评估的关系.pdf
- use of rna interference by in utero electroporation to study cortical development the example of the doublecortin superfamily利用rna干扰在子宫内电穿孔研究皮质发展的例子doublecortin总科.pdf
- use of zebrafish to probe the divergent virulence potentials and toxin requirements of extraintestinal pathogenic escherichia coli利用斑马鱼探针不同毒力势和毒素extraintestinal致病性大肠杆菌的要求.pdf
- usefulness of dismissing and changing the coach in professional soccer有用的解雇和改变在职业足球教练.pdf
- use of tissue-specific microrna to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells使用组织微控制病理无衰减的野生型腺病毒杀死癌细胞的能力.pdf
- usefulness of mendelian randomization in observational epidemiology有效性的观察性流行病学孟德尔随机化.pdf
- use of parsimony analysis to identify areas of endemism of chinese birds implications for conservation and biogeography使用精简分析识别领域的特有现象的中国鸟类保护和生物地理学的影响.pdf
- virtual globes serving science and society虚拟地球仪科学与社会服务.pdf
- virologic failure of protease inhibitor-based second-line antiretroviral therapy without resistance in a large hiv treatment program in south africa病毒蛋白酶inhibitor-based二线抗逆转录病毒疗法的失败无电阻在一个大的艾滋病毒治疗项目在南非.pdf
- viral sequestration of antigen subverts cross presentation to cd8+ t cells病毒的抗原封存颠覆了十字架表示cd8 + t细胞.pdf
- virtual hand illusion induced by visuomotor correlations虚拟手visuomotor相关性引起的错觉.pdf
- virtual astronaut for scientific visualization—a prototype for santa maria crater on mars虚拟宇航员科学visualization-a原型圣玛丽亚火星陨石坑.pdf
- virtual mutagenesis of the yeast cyclins genetic network reveals complex dynamics of transcriptional control networks酵母细胞周期蛋白基因网络的虚拟诱变揭示复杂的动态转录控制网络.pdf
- virtual screening as a strategy for the identification of xenobiotics disrupting corticosteroid action虚拟筛选的策略识别外源性物质破坏皮质类固醇的行动.pdf
- virtual screening of specific insulin-like growth factor 1 receptor (igf1r) inhibitors from the national cancer institute (nci) molecular database虚拟筛选特定的胰岛素样生长因子1受体(igf1r)从美国国家癌症研究所(nci)抑制剂分子数据库.pdf
- viral small interfering rnas target host genes to mediate disease symptoms in plants病毒小干扰rna基因目标主机调解植物疾病症状.pdf
- virtual screening, identification and in vitro testing of novel inhibitors of o-acetyl-l-serine sulfhydrylase of entamoeba histolytica虚拟筛选、鉴定和体外测试新型抑制剂o-acetyl-l-serine sulfhydrylase痢疾阿米巴.pdf
文档评论（0）