viral replication rate regulates clinical outcome and cd8 t cell responses during highly pathogenic h5n1 influenza virus infection in mice病毒复制的速度调节临床结果和cd8 t细胞反应在高致病性h5n1流感病毒感染小鼠.pdfVIP

Viral Replication Rate Regulates Clinical Outcome and CD8 T Cell Responses during Highly Pathogenic H5N1 Influenza Virus Infection in Mice 1,2. 1,2. 3 4 2 Yasuko Hatta , Karen Hershberger , Kyoko Shinya , Sean C. Proll , Richard R. Dubielzig , Masato 1,2 4 1,2,5 1,2 Hatta , Michael G. Katze , Yoshihiro Kawaoka *, M. Suresh * 1 Influenza Research Institute, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 2 Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 3 Division of Zoonosis, Department of Microbiology and Infectious Disease, Graduate School of Medicine, Kobe University, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan, 4 Department of Microbiology, School of Medicine, University of Washington, Seattle, Washington, United States of America, 5 Division of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan Abstract Since the first recorded infection of humans with H5N1 viruses of avian origin in 1997, sporadic human infections continue to occur with a staggering mortality rate of .60%. Although sustained human-to-human transmission has not occurred yet, there is a growing concern that these H5N1 viruses might acquire this trait and raise the specter of a pandemic. Despite progress in deciphering viral determinants of pathogenicity, we still lack crucial information on virus/immune system interactions pertaining to severe disease and high mortality as