visual genome-wide rnai screening to identify human host factors required for trypanosoma cruzi infection视觉全基因组rnai筛选识别人类宿主因素所需鲁兹锥体感染.pdfVIP

Visual Genome-Wide RNAi Screening to Identify Human Host Factors Required for Trypanosoma cruzi Infection 1. 2. 3,4. 2 Auguste Genovesio , Miriam A. Giardini , Yong-Jun Kwon , Fernando de Macedo Dossin , Seo Yeon 3 3 3 3 5 6 Choi , Nam Youl Kim , Hi Chul Kim , Sung Yong Jung , Sergio Schenkman , Igor C. Almeida , Neil 7 2 Emans *, Lucio H. Freitas-Junior * 1 Image Mining Group, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea, 2 Center for Neglected Diseases Drug Discovery, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea, 3 Discovery Biology Group, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea, 4 Department of Biochemistry and ˜ National Research Laboratory, Yonsei University, Seoul, South Korea, 5 Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sao Paulo, ˜ ˜ Sao Paulo, Sao Paulo, Brazil, 6 Department of Biological Sciences, The Border Biomedical Research Center, University of Texas at El Paso, El Paso, Texas, United States of America, 7 High Throughput Biology Group, Synthetic Biology ERA, CSIR Biosciences, Pretoria, South Africa Abstract The protozoan parasite Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical infection that affects millions of people in the Americas. Current chemotherapy relies on only two drugs that have limited efficacy and