原创力文档uterine nk cells are critical in shaping dc immunogenic functions compatible with pregnancy progression子宫nk细胞是至关重要的在塑造dc免疫原性的功能兼容怀孕进展.pdfVIP
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uterine nk cells are critical in shaping dc immunogenic functions compatible with pregnancy progression子宫nk细胞是至关重要的在塑造dc免疫原性的功能兼容怀孕进展
Uterine NK Cells Are Critical in Shaping DC Immunogenic
Functions Compatible with Pregnancy Progression
´ 1. 1,2. 1 3 4
Irene Tirado Gonzalez , Gabriela Barrientos , Nancy Freitag , Teresa Otto , Victor L. J. L. Thijssen ,
1 1 1 3 5
Petra Moschansky , Petra von Kwiatkowski , Burghard F. Klapp , Elke Winterhager , Stefan Bauersachs ,
Sandra M. Blois1*
´ ´
1 Medicine University of Berlin, Charite Centre 12 Internal Medicine and Dermatology, Laboratory of Reproductive Medicine, Berlin, Germany, 2 Laboratorio de Fisiologıa
´ ´
Molecular Placentaria, Departamento de Quımica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina, 3 Institute of
Molecular Biology, University Hospital, University Duisburg-Essen, Essen, Germany, 4 Department of Radiotherapy, Angiogenesis Laboratory, VU University Medical Center,
Amsterdam, The Netherlands, 5 Chair for Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany
Abstract
Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity,
but their relevance during early pregnancy remains elusive. Using two different strategies to manipulate the frequency of
NK cells and DC during gestation, we investigated their relativ
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