comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen比较基因组分析铜转运蛋白和cuproproteomes揭示演化动力学的铜氧利用率及其链接.pdfVIP

Comparative Genomic Analyses of Copper Transporters and Cuproproteomes Reveal Evolutionary Dynamics of Copper Utilization and Its Link to Oxygen Perry G. Ridge, Yan Zhang, Vadim N. Gladyshev* Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, United States of America Copper is an essential trace element in many organisms and is utilized in all domains of life. It is often used as a cofactor of redox proteins, but is also a toxic metal ion. Intracellular copper must be carefully handled to prevent the formation of reactive oxygen species which pose a threat to DNA, l