comparison of the frequency of functional sh3 domains with different limited sets of amino acids using mrna display比较功能sh3域的频率不同的有限集的氨基酸使用信使rna显示.pdfVIP

Comparison of the Frequency of Functional SH3 Domains with Different Limited Sets of Amino Acids Using mRNA Display Junko Tanaka, Hiroshi Yanagawa, Nobuhide Doi* Department of Biosciences and Informatics, Keio University, Yokohama, Japan Abstract Although modern proteins consist of 20 different amino acids, it has been proposed that primordial proteins consisted of a small set of amino acids, and additional amino acids have gradually been recruited into the genetic code. This hypothesis has recently been supported by comparative genome sequence analysis, but no dir