crystal structure of human akt1 with an allosteric inhibitor reveals a new mode of kinase inhibition晶体结构的人类akt1变构抑制剂揭示激酶抑制的新模式.pdfVIP

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition Wen-I Wu, Walter C. Voegtli, Hillary L. Sturgis, Faith P. Dizon, Guy P. A. Vigers, Barbara J. Brandhuber* Department of Structural Biology, Array BioPharma Inc., Boulder, Colorado, United States of America Abstract AKT1 (NP_005154.2) is a member of the serine/threonine AGC protein kinase family involved in cellular metabolism, growth, proliferation and survival. The three human AKT isozymes are highly homologous multi-domain proteins