differential immediate and sustained memory enhancing effects of alpha7 nicotinic receptor agonists and allosteric modulators in rats微分立即和持续的记忆增强效应alpha7烟碱受体受体激动剂在老鼠和变构调节剂.pdfVIP

Differential Immediate and Sustained Memory Enhancing Effects of Alpha7 Nicotinic Receptor Agonists and Allosteric Modulators in Rats 1 1 1,2 Morten S. Thomsen *, Mona El-Sayed , Jens D. Mikkelsen 1 Neurobiology Research Unit, University Hospital Copenhagen, Copenhagen, Denmark, 2 Neurosearch A/S, Ballerup, Denmark Abstract The a7 nicotinic acetylcholine receptor (nAChR) is a potential target for the treatment of cognitive deficits in patients with schizophrenia, ADHD and Alzheimer’