disco-sca and properly applied gsvd as swinging methods to find common and distinctive processesdisco-sca和正确应用定理摆动方法找到共同和独特的过程.pdfVIP
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disco-sca and properly applied gsvd as swinging methods to find common and distinctive processesdisco-sca和正确应用定理摆动方法找到共同和独特的过程
DISCO-SCA and Properly Applied GSVD as Swinging
Methods to Find Common and Distinctive Processes
1 1 2,3,4 1 3
Katrijn Van Deun *, Iven Van Mechelen , Lieven Thorrez , Martijn Schouteden , Bart De Moor ,
¨ 5, Lieven De Lathauwer3,6, Age K. Smilde7, Henk A. L. Kiers8
Mariet J. van der Werf
1 Department of Psychology, Katholieke Universiteit Leuven, Leuven, Belgium, 2 Translational Cardiomyology, Stem Cell Institute Leuven Department of Development
and Regeneration, Katholieke Universiteit Leuven, Leuven, Belgium, 3 Department Electrical Engineering (ESAT-SCD), Katholieke Universiteit Leuven/IBBT Future Health
Department, Kasteelpark Arenberg 10, Leuven, Belgium, 4 Interdisiciplinary Research Center, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium, 5 TNO,
Quality of Life, Zeist, The Netherlands, 6 Group Science, Engineering and Technology, Katholieke Universiteit Leuven Campus Kortrijk, Kortrijk, Belgium, 7 Biosystems data
analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands, 8 Heymans Institute, University of Groningen, Groningen, The
Netherlands
Abstract
Background: In systems biology it is common to obtain for the same set of biological entities information from multiple
sources. Examples include expression data for the same set of orthologous genes screened in different organisms and data
on the same set of culture samples obtained with different high-throughput techniques. A major challenge is to find the
important biological processes underlying the data and to disentangle therein processes common to all data sources and
processes distinctive for a specific source. Recently, two pr
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