diversification of specificity after maturation of the antibody response to the hiv gp41 epitope eldkwa多样化的特异性抗体反应成熟后艾滋病gp41抗原决定基eldkwa.pdfVIP

Diversification of Specificity after Maturation of the Antibody Response to the HIV gp41 Epitope ELDKWA Henry N. White*, Qing-Hai Meng Department of Molecular Immunology, University College London, Institute of Child Health, London, United Kingdom Abstract During maturing antibody responses the increase in affinity for target antigens is achieved by genetic diversification of antibody genes followed by selection for improved binding. The effect this process has on the specificity of antibody for variants of the antigen is not well-defined, despite th