dna vaccination partially protects against african swine fever virus lethal challenge in the absence of antibodiesdna疫苗接种部分保护非洲猪瘟病毒致命的挑战没有抗体.pdfVIP

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dna vaccination partially protects against african swine fever virus lethal challenge in the absence of antibodiesdna疫苗接种部分保护非洲猪瘟病毒致命的挑战没有抗体.pdf

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dna vaccination partially protects against african swine fever virus lethal challenge in the absence of antibodiesdna疫苗接种部分保护非洲猪瘟病毒致命的挑战没有抗体

DNA Vaccination Partially Protects against African Swine Fever Virus Lethal Challenge in the Absence of Antibodies 1¤a ´ ´ 1¤b ´ 1 2 1,5 Jordi M. Argilaguet , Eva Perez-Martın , Miquel Nofrarıas , Carmina Gallardo , Francesc Accensi , 1 1 1 1 ´ 1 Anna Lacasta , Mercedes Mora , Maria Ballester , Ivan Galindo-Cardiel , Sergio Lopez-Soria , ´ 3 4 ´ 1 Jose M. Escribano , Pedro A. Reche , Fernando Rodrıguez * ´ 1 Centre de Recerca en Sanitat Animal (CReSA), UAB-IRTA, Bellaterra, Barcelona, Spain, 2 CISA-INIA, Valdeolmos, Madrid, Spain, 3 Departamento de Biotecnologıa, INIA, ´ Madrid, Spain, 4 Departamento de Microbiologıa I, Universidad Computense de Madrid (UCM), Madrid, Spain, 5 Departament de Sanitat I Anatomia Animals, Universitat ` Autonoma de Barcelona (UAB), Bellaterra, Barcelona, Spain Abstract The lack of available vaccines against African swine fever virus (ASFV) means that the evaluation of new immunization strategies is required. Here we show that fusion of the extracellular domain of the ASFV Hemagglutinin (sHA) to p54 and p30, two immunodominant structural viral antigens, exponentially improved both the humoral and the ce