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Effects of Kisspeptin1 on Electrical Activity of an Extrahypothalamic Population of Gonadotropin- Releasing Hormone Neurons in Medaka (Oryzias latipes) Yali Zhao, Nancy L. Wayne* Department of Physiology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America Abstract Kisspeptin (product of the kiss1 gene) is the most potent known activator of the hypothalamo-pituitary-gonadal axis. Both kiss1 and the kisspeptin receptor are highly expressed in the hypothalamus of vertebrates, and low doses of kisspeptin