enhanced chromatin accessibility and recruitment of junb mediate the sustained il-4 expression in nfat1 deficient t helper 2 cells增强染色质junb调解的可访问性和招聘持续表达il - 4 nfat1不足2辅助t细胞.pdfVIP

Enhanced Chromatin Accessibility and Recruitment of JUNB Mediate the Sustained IL-4 Expression in NFAT1 Deficient T Helper 2 Cells Jun-Seock Son, Chang-Suk Chae, Ji-Sun Hwang, Zee Yong Park, Sin-Hyeog Im* School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea Abstract Nuclear factor of activated T cells (NFAT) is a family of transcription factors composed of five proteins. Among them, NFAT1 is a predominant NFAT protein in CD4+ T cells. NFAT1 positively regulates transcription