阿奇霉素分散片（Azithromycin Dispersible Tablets）.docVIP

阿奇霉素分散片（Azithromycin Dispersible Tablets） 阿奇霉素分散片 (azithromycin dispersible tablets) (君洁) 本品主要成份为阿奇霉素, 其他学名称为 (2r, 3s, 4r, 5r, 8r, 10r, bovine 11r, 12s, and applications to set them) - 13 - ［ (2.6 - 二脱氧3 - c - 甲基 - 3 or - 甲基 - to - the - 核 - 已吡喃糖基) 氧］ - 2 - 乙基 - 3,4,10 - 三羟基 - 3,5,6,8,10,12,14 - 七甲基 - 11 - ［［3,4,6 - 三脱氧) - 3 - (二甲氨基) - b - d - 木 - 已吡喃糖基］氧］ - 1 - 氧杂 - 6 - 氮杂环十五烷 - 15酮. 【性状】 本品为白色片. 【药理毒理】 阿奇霉素系通过阻碍细菌转肽过程, 从而抑制细菌蛋白质的合成, 体外试验证明阿奇霉素对临床上多种常见致病菌有抗菌作用, 包括: 革兰阳性需氧菌: 金黄色葡萄球菌、酿脓链球菌 (a组b溶血性链球菌) 、肺炎 (链) 球菌、a - 溶血性链球菌 (草绿色链球菌) 和其它链球菌、白喉 (棒状) 杆菌.本品对于耐红霉素的革兰阳性细菌, 包括粪链球菌 (肠球菌) 以及耐甲氧西林的多种葡萄球菌菌株呈现交叉耐药性. 革兰阴性需氧菌: 流感 (嗜血) 杆菌、副流感 (嗜血) 杆菌、卡他 (摩拉) 菌、不动杆菌属、耶尔森菌属、嗜肺军团菌、百日咳杆菌、副百日咳杆菌、志贺菌属、巴斯德菌属、霍乱弧菌、副溶血性杆菌、类志贺吡邻单胞菌. This product is sensitive to the activity of the following gram negative bacteria, and should be determined by sensitivity: Escherichia coli, Salmonella typhi, Enterobacteriaceae, Aeromonas hydrophila and klebsiella. Anaerobes: Bacteroides fragilis, Bacteroides, Bacillus perfringens, Streptococcus spp., Clostridium perfringens and Propionibacterium acnes. Sexually transmitted diseases microorganisms: Treponema pallidum, Neisseria gonorrhoeae, Duke (Haemophilus) bacillus. Other microorganisms: including Tettnang Borrelia (Lyme disease), Mycoplasma pneumoniae, Mycoplasma hominis, Ureaplasma urealyticum, Chlamydia trachomatis, Pneumocystis carinii, Mycobacterium avium spp., Campylobacter coli and mononuclear cells of Li Side increased. The following gram negative bacteria are usually resistant: Proteus, Sarre, Morgan, and Pseudomonas aeruginosa. The mechanism of action is the same as that of erythromycin, which mainly combines with 50S subunit of bacterial ribosome and inhibits the synthesis of protein dependent on RNA. [pharmacokinetics] Rapidly absorbed after oral administration, with a bioavailability of 37%. After single oral administration of 0.5g, the peak time was 2.5 to 2.6 hours, and the peak concentration of blood drug (Cmax) was 0.4 ~ 0.45mg/L. This produc