脊髓损伤药物治疗（Spinal cord injury, drug therapy）.docVIP

脊髓损伤药物治疗（Spinal cord injury, drug therapy） Send text messages to friends Spinal cord injury, drug therapy This article is from China critical care medicine network. The source of the article is: http: ///Article/senj/200706/Article_68203.html Spinal cord injuries are common injuries, and in the United States, about 10000 people suffer from severe spinal cord injuries each year. Majority Injuries are caused by traffic trauma, falling injuries, violent or athletic injuries. Especially painful is the majority of patients with spinal cord injury The number of healthy young adults often carries a heavy social burden, and the United States spends annually on spinal cord injuries 30~40 billion [1, 2]. Therefore, it is important to study the treatment of spinal cord injury. 1. neurotrophic factors It has been widely reported that nerve growth factor (NGF) can promote the survival and growth of peripheral nerve neurons The role of the central nervous system was first reported by Scott and Liu in 1963. Neurotrophic factors are now known Is a large family that includes brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-) (3) and ciliary nerve growth factor (CNTF); these neurotrophic factors are involved in the central nervous system injury More and more attention has been paid to the treatment. The use of neurotrophic factors in animal models for spinal cord injury indicates that it is possible To prevent the spinal cord red nucleus neurons atrophy, enhance corticospinal tract germination and promote regeneration of rubrospinal nerve pathway; Both BDNF and NT-3 can prevent axonal axotomy in adult rat red nucleus spinal cord cell death, and BDNF and NT-3 also Capable of rescuing dying neurons, Promote axonal regeneration of [3]; within 5~8 h after injury, BDNF or NT-3 can be significant Increase the survival rate of neurons. Combined use of BDNF and NT-3 allows the transplanted nerve cells to survive and reduce the presence of God Meta apoptosis. Neurotrophic facto