阿奇霉素联合头孢丙烯治疗儿童上呼吸道感染疗效分析.docVIP

阿奇霉素联合头孢丙烯治疗儿童上呼吸道感染疗效分析 　【摘要】; 目的; 评价阿奇霉素联合头孢丙烯儿童上呼吸道细菌性感染的疗效和安全性。; 采用随机双盲对照的方法，入选条件为临床表现有发热（体温gt;37.5℃）、咽喉肿痛、咽、扁桃腺充血、咳嗽等，血白细胞总数gt;10×109/L，和/或中性粒细胞比例升高。分3组，每组40例，A组口服希舒美，10mg·kg-1·d-1，每日1次，连服3d；B组口服施复捷，15mg·kg-1·d-1，每日2次，连服10天；C组口服希舒美和施复捷，剂量和疗程同上。观察指标为体温、血白细胞数，疗效判断标准分为治愈、显效、进步和无效。结果; A组（希舒美组）治愈26例，显效5例，进步4例，无效5例，总有效率为77.5%，不良反应为腹泻、呕吐2例，不良反应发生率为5%。B组（施复捷组）治愈27例，显效5例，进步4例，无效4例，总有效率为80%，不良反应为腹泻1例，皮疹1例，不良反应发生率为5%。C组治愈34例，显效4例，进步1例，无效1例，总有效率为95%；不良反应为腹泻、呕吐2例，皮疹1例，不良反应发生率为7.5%。所有病例均未因不良反应而中断治疗。A组与B组之间疗效比较，χ2=0.08，Pgt;0.05，差异无显著性；A组与C组之间疗效比较，χ2=5.16，P=0.023，差异有显著性；B组与C组之间疗效比较，χ2=4.11，P=0.0425，差异有显著性。C组不良反应发生率与A组或B组比较（A组和B组的不良反应发生率相同），χ2=0.17，Pgt;0.05，差异无显著性。结论 阿奇霉素治疗儿童上呼吸道细菌性感染有效，头孢丙烯治疗儿童上呼吸道细菌性感染有效，阿奇霉素联合头孢丙烯治疗儿童上呼吸道细菌感染疗效更好，优于单药给药，不良反应并未因联合治疗而增多，安全性好。 ; 【关键词】; 阿奇霉素; 头孢丙烯; 联合治疗; 儿童; 上呼吸道感染 ; Effect of azithromycin combined with cefprozil on treatment with childrens upper respiratory infections ; 【Abstract】; Objective; To evaluate the effects and side effects of azithromycin(zithromax) combined with cefprozil( cefzil) on treatment with childrens upper respiratory infections.Methods; patients who suffered from upper respiratory infections with body temperature over 37.5 ℃ as well as white blood cells over 10×109/L were selected for treatment randomly and double-blindedly. These cases were divided by 3 groups， each group having 40 cases.Cases of group A were administered with zithromax 10mg·kg-1·d-1，once a day， continued with 3 days. Cases of group B were administered with cefzil 15mg·kg-1·d-1， twice a day， with 10 days continuously. Cases of group C were administered with both zithromax and cefzil as the same dose and duration as group A and group B. Changes of body temperature and white blood cells were considered as index to judge the effects of treatment. The criteria of judgement were divided as cure， markedly improved ， improved and failed.Results; In group A， 26 of 40 cases being cured， 5 of 40 cases being markedly improved， 4 of 40 cases being improved， while 5 o