妊娠期高血压病患者血清及胎盘IL-4水平变化及意义.docVIP

妊娠期高血压病患者血清及胎盘IL-4水平变化及意义 　【摘要】 目的 观察妊娠期高血压病患者血清与胎盘白介素4(IL-4)水平的变化，探讨这些变化与妊娠期高血压病的关系。 方法 本院37例妊娠期高血压病患者和32例正常孕妇（对照组），采用放射免疫分析法测定血清和胎盘组织提取液中IL-4浓度，比较妊娠期高血压病组与对照组血清、胎盘IL-4水平的差异。结果 与对照组比较，妊娠期高血压病组血清IL-4水平增高，差异有显著性(Plt;0.05)；妊娠期高血压病组胎盘IL-4水平高于对照组，差异接近但尚未达到显著性水平（Pgt;0.05）。妊娠期高血压、轻度、重度子前期患者血清和胎盘IL-4水平差异均无显著性（Pgt;0.05）。妊娠期高血压病组血清与胎盘IL-4水平均无显著相关性（Pgt;0.05）。结论 血清IL-4水平增高是妊娠期高血压病的重要病理变化，可能在妊娠期高血压病的发生与变化发展过程中起了作用。 【关键词】 妊娠期高血压病 白介素4 胎盘 血清 细胞因子 【Abstract】 Objective To observe the change of IL-4 in both serum and placenta in hypertension disordercomplicating pregnancy and to explore their relationshiops. Methods 37 patients with hypertension disorder complicating pregnany and 32 normal pregnant woman were enrolled in this study , the concentration of their IL-4 in both their serum and placenta tissue extract were measured with radio immunoassay and the difference was statistically compared and analyzed . Results Compared with that of control group ,the serum level of IL-4 of hypertension disordercomplicating pregnancy was significantly higher (Plt;0.05); the level of IL4 in placenta in hypertension disordercomplicating pregnancy was higher ,but the difference was not significant（Pgt;0.05）.There was no significant difference in levels of of IL4 in both serum and placenta in hypertension disordercomplicating pregnancy of slight degree ,sever degree or eclampsism（Pgt;0.05）. There was no correlation between the IL4 level in serum and placenta in hypertension disordercomplicating pregnancy group（Υ=0.145，Pgt;0.05及Υ=0.122，Pgt;0.05）. Conclusions The rise in serum level of IL—4 is an important pathological change in hypertension disordercomplicating pregnancy,which may play a role in the and development of hypertension disordercomplicating pregnancy 【Key Words】 Hypertension disordercomplicating pregnary IL-4 placenta serum cell factor 　　妊娠期高血压病是严重危害母婴健康的妊娠晚期并发症，其病因与发病机制尚未阐明［１］；免疫学病因与发病机制是近年来国内外学者关注的重点，细胞因子与妊娠期高血压病的关系也引起了注意［２，３］。白介素4（IL-4）是一种Th2型细胞因子，在子宫内膜、蜕膜与胎盘组织中持续表达，正常妊娠时外周血单个核细胞