丙烯酸树脂系列辅料在药物新剂型中的应用-药学实践杂志.PDFVIP

12 The Journal of Pharmaceutical Practice Vol.20 2002 No. 1 1 2 2 1 刘善奎, 钟延强, 孙其荣, 张卫星( 1 , 250031;2 , 200433) 本文对丙烯酸树脂系列辅料在缓释微 丸缓释骨架 固体分散体微球和微囊口服结肠定位给药系 统及透皮给药系统等药物新剂型中的应用进行了综述, 认为: 随着新型丙烯酸树脂的研究开发, 其在药物新 剂型的应用更加广泛 丙烯酸树脂; 包衣;骨架材料; 缓(控)释制剂 : : : 1006- 0111(2002)01- 0012- 04 Application of acrylic resins in new dosage forms of pharmceutics 1 2 2 1 LIU Shankui , ZHONG Yanqiang , SUN irong , ZHANG Weixing ( 1General Hospital of Jinan Military Region, Jinan 250031,China;2College of Pharmacy,Second Military Medical University,Shanghai 200433,China) ABSTRACT Arcylic resin is one of the widely used drug excipients, which can be used as drug adhesive, coating, matrix, carrier, encapsulating material for preparing sustained release pellets, sustained releasetablets, solid dispersion, microspheres, microencapsules, oral colonic targeting delivery systems and transdermal delivery system and so on.This paper reviews theproperty and application of arylic resin in pharmaceutics. KEY WORDS acrylic resin; coating; matrix; sustained or controlled release , , ,, [ 2] , , Eudragit L30D, ,,, 2070 , , , ,, , PVP , , [1] 2 , , , , Eudragit E Eudragit E30D, Eudragit L30D, Eudragit L/ S, ,Eudragit L Eudragit S Eudragit RL/ RS,Eudragit Retard Eudragit E100 Eudragit E30DpH , , 30~ 60s , ,Eudragit E30D , ( PVA,PVP,PEG) , , Eudragit L( ) ,Eudragit S ( , ) Eudragit L pH 60 ,Eudragit S pH 70 , , , ( 10~ 40%) , ,