(消化道初级感觉神经元).pptVIP

Primary afferent neurons of the gut （消化道初级感觉神经元） Function: Monitoring and control of the digestive system, including: Generating appropriate reflex response to the gut lumen contents Participates in reflexes between organs Convey signals from digestive organs to the CNS – Trigger reflex Co-ordination with other body system Relate to sensation including discomfort, nausea, pain and satiety;intrinsic and extrinsic 内源性和外源性;Intrinsic primary afferent neurons, IPANs, within ENS;I Intrinsic Primary Afferent Neurons and Nerve Circuits within the Intestine;Types of neurons that form enteric nerve circuits According to the functions, key transmitters projections to targets ;LM: longitudinal muscle; MP: myenteric plexus; CM: circular muscle; SM: submucosal plexus; Muc: mucosa. ;LM: longitudinal muscle; MP: myenteric plexus; CM: circular muscle; SM: submucosal plexus; Muc: mucosa;2. Characteristics of intrinsic primary afferent neurons (IPANs);2. Characteristics of IPANs- Conti;2. Characteristics of intrinsic afferent neurons- Conti;2. Characteristics of IPANs- Conti;Mucosal mechanoreceptors: Puffs of nitrogen gas on the mucosal induce C-Fos expression in IPAN Blocked by TTX Unaffected by hexamethonium (六甲铵), the nicotinic receptor antagonist Mostly indirect, through the release of 5-HT from enterochromaffin cells (肠嗜铬细胞) in the mucous membrane (粘膜);3. Enteric nerve circuits Intrinsic reflexes that affect motility, water and electrolyte secretion and blood flow all occur in the intestine Circuits for motility control;Secretomotor and vasomotor reflexes;II Extrinsic Primary Afferent Neurons The rich sensory innervation (神经支配) of the gastrointestinal tract comprise: Intrinsic sensory neurons contained entirely within the gastrointestinal wall Intestinofugal fibres 肠离心神经纤维 that project to prevertebral ganglia (椎前神经节) Vagal and spinal afferent that projects to the central nervous system. ;16;Pathway to the central nervous system (1) Vagus Afferent （迷走神经传入纤维）;Projection from