the role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses干扰素拮抗剂的作用,非结构性蛋白质的发病机理和虫媒病毒的出现.pdfVIP

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the role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses干扰素拮抗剂的作用,非结构性蛋白质的发病机理和虫媒病毒的出现.pdf

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the role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses干扰素拮抗剂的作用,非结构性蛋白质的发病机理和虫媒病毒的出现

Viruses 2011, 3, 629-658; doi:10.3390/v3060629 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review The Role of Interferon Antagonist, Non-Structural Proteins in the Pathogenesis and Emergence of Arboviruses Bradley S. Hollidge 1,2, Susan R. Weiss 3 and Samantha S. Soldan 1,* 1 Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA; E-Mail: hollidge@ 2 Neuroscience Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA 3 Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA; E-Mail: weisssr@ * Author to whom correspondence should be addressed; E-Mail: sssoldan@; Tel.: +1-215-898-3502; Fax: +1-215-573-2029. Received: 5 April 2011; in revised form: 4 May 2011 / Accepted: 7 May 2011/ Published: 1 June 2011 Abstract: A myriad of factors favor the emergence and re-emergence of arthropod-borne viruses (arboviruses), including migration, climate change, intensified livestock production, an increasing volume of international trade and transportation, and changes to ecosystems (e.g., deforestation and loss of biodiversity). Consequently, arboviruses are distributed worldwide and represent over 30% of all emerging infectious diseases identified in the past decade. Although some arboviral infections go undetected or are associated with mild, flu-like symptoms, many are important human