the sensory consequences of speaking parametric neural cancellation during speech in auditory cortex感觉说话的后果参数在听觉皮层神经期间取消演讲.pdfVIP

The Sensory Consequences of Speaking: Parametric Neural Cancellation during Speech in Auditory Cortex 1 2 3 2 1,4 Ingrid K. Christoffels *, Vincent van de Ven , Lourens J. Waldorp , Elia Formisano , Niels O. Schiller 1 Leiden Institute of Brain and Cognition (LIBC) and Leiden Institute of Psychological Research, Leiden University, Leiden, The Netherlands, 2 Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands, 3 Psychological Methods, Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands, 4 Netherlands Institute for Advanced Study (NIAS) in the Humanities and Social Sciences, Wassenaar, The Netherlands Abstract When we speak, we provide ourselves with auditory speech input. Efficient monitoring of speech is often hypothesized to depend on matching the predicted sensory consequences from internal motor commands (forward model) with actual sensory feedback. In this paper we tested the forward model hypothesis using functional Magnetic Resonance Imaging. We administered an overt picture naming task in which we parametrically reduced the quality of verbal feedback by noise masking. Presentation of the same auditory input in the absence of overt speech served as listening control condition. Our results suggest that a match between predicted and actual sensory feedback results in inhibition of cancellation of auditory activity because speaking with normal unmasked feedback reduced activity in the auditory cortex compared to listening control conditions. Moreover, during self-generated speech, activation in auditory cortex increased as the feedback quality of the self-generated speech decreased. We