原创力文档the study of the inhibition of the recombinant tace prodomain to endotoxemia in mice研究抑制内毒素的重组栓塞prodomain老鼠.pdfVIP
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the study of the inhibition of the recombinant tace prodomain to endotoxemia in mice研究抑制内毒素的重组栓塞prodomain老鼠
Int. J. Mol. Sci. 2009, 10, 5442-5454; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
The Study of the Inhibition of the Recombinant TACE
Prodomain to Endotoxemia in Mice
1 2 2 2,
Xiaoou Li , Yuan Yan , Wei Huang and Yuzhen Yang *
1 Department of Pediatrics, Renming Hospital, Wuhan University, Wuhan 430044, China;
E-Mail: lxou27@
2 Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University
of Science Technology, Wuhan 430030, China; E-Mails: Yanyuan@ (Y.Y.);
huangwei@ (W.H.)
* Author to whom correspondence should be addressed; E-Mail: yangyz@.
Received: 9 October 2009 / Accepted: 17 December 2009 / Published: 18 December 2009
Abstract: Objective: To demonstrate the inhibitory function of the prodomain of tumor
necrosis factor-α (TNF-α) converting enzyme (TACE) on TACE activity and to develop an
approach to interfere with inflammation processes. Methods: The cDNA encoding the full-
length ectodomain (T1300) and prodomain (T591) of TACE were amplified by RT-PCR.
The expression plasmids (pET-28a (+)-T1300 and pET-28a (+)-T591) were constructed
and transformed into E. coli BL21. After Ni2+-NTA resin affinity chromatography, the
recombinant T591 protein was obtained and assayed. In
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