the tandem ccch zinc finger protein tristetraprolin and its relevance to cytokine mrna turnover and arthritis串联ccch锌指蛋白tristetraprolin及其相关细胞因子mrna营业额和关节炎.pdfVIP

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the tandem ccch zinc finger protein tristetraprolin and its relevance to cytokine mrna turnover and arthritis串联ccch锌指蛋白tristetraprolin及其相关细胞因子mrna营业额和关节炎.pdf

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the tandem ccch zinc finger protein tristetraprolin and its relevance to cytokine mrna turnover and arthritis串联ccch锌指蛋白tristetraprolin及其相关细胞因子mrna营业额和关节炎

Arthritis Research Therapy Vol 6 No 6 Carrick et al. Review The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis 1 2 1,2,3 Danielle M Carrick , Wi S Lai and Perry J Blackshear 1Office of Clinical Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA 2Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA 3Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina, USA Corresponding author: Perry J Blackshear, black009@ Published: 8 October 2004 Arthritis Res Ther 2004, 6:248-264 (DOI 10.1186/ar1441) © 2004 BioMed Central Ltd Abstract Tristetraprolin (TTP) is the best-studied member of a small family of three proteins in humans that is characterized by a tandem CCCH zinc finger (TZF) domain with highly conserved sequences and spacing. Although initially discovered as a gene that could be induced rapidly and transiently by the stimulation of fibroblasts with growth factors and mitogens, it is now known that TTP can bind to AU- rich elements in mRNA, leading to the removal of the poly(A) tail from that mRNA and increased rates of mRNA turnover. This activity was discovered after TTP-deficient mice were created and found to have a systemic inflammatory syndrome with severe polyarticular arthritis and autoimmunity, as well as medullary and extramedullary myeloid hyperplasia. The syndrom