the time delay between drug intake and bronchospasm for nonsteroidal antiinflammatory drugs sensitive patients药物摄入量之间的时间延迟和非甾体类抗炎药物敏感患者支气管痉挛.pdfVIP

ORIGINAL ARTICLE The Time Delay Between Drug Intake and Bronchospasm for Nonsteroidal Antiinflammatory Drugs Sensitive Patients 1,2 3 1,4 Giedre Grigiene, MD, Jolita Norku niene˙, PhD, and Violeta Kvedariene, MD, PhD life-threatening, requiring hospital admission, and, at times, Abstract: A study was performed to assess the time between drug requiring mechanical ventilation. Up to 25% of hospital intake and drug induced hypersensitivity reaction for patients sen- admissions for acute asthma requiring mechanical ventilation sitive to nonsteroidal antiinflammatory drugs (NSAID) in clinical may be because of nonsteroidal antiinflammatory drugs patient history and after oral provocation tests. Drug hypersensitivity (NSAID) ingestion.5 ENDA questionnaires were filled for the patients with suspected The diagnosis of aspirin intolerance was based on a sensitivity to NSAID. Oral provocation tests were performed with typical history confirmed by positive aspirin provocation suspected NSAID according to the ENDA/EAACI recommenda- tests.6 Differences in populations studied, methods used, tions. There were 76 patients with history of hypersensitivity reac- definitions of outcomes, and criteria for defining sensitiv- tions after use of NSAID enrolled in the study. Recorded were 154 ity