绝经后妇女糖代谢的变化（Changes of glucose metabolism in postmenopausal women）.doc

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绝经后妇女糖代谢的变化（Changes of glucose metabolism in postmenopausal women）.doc

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绝经后妇女糖代谢的变化（Changes of glucose metabolism in postmenopausal women）

绝经后妇女糖代谢的变化（Changes of glucose metabolism in postmenopausal women） Changes of glucose metabolism in postmenopausal women 2010-06-01 Wu Jie, Bi Yucheng, Wang Haiqi The loss of ovarian function may increase the risk of cardiovascular disease, lipid metabolism and cardiovascular risk factors in postmenopausal women in the exception has been confirmed by the 1 scholars, but the changes of glucose metabolism associated with menopause but few studies. The purpose of this study is to investigate the changes of glucose metabolism in postmenopausal women. First, objects and methods 1. objects (1) control group: 8 cases, aged 34~39 years, average 36 + 2 years old, normal menstruation, body mass index (BMI), =23.26 + 1.37kg/m2. (2) menopause group: 15 cases, age 49~63 years old, average 57 + 4 years old, menopause 5~16 years, average 10 + 4 years, BMI=23.98 + 1.34kg/m2. 2. method All of the subjects in the morning fasting and quiet under the state of oral glucose tolerance test (OGTT) and intravenous glucose tolerance test sample (FSIGT), blood glucose, insulin and C- peptide (the control group in the menstrual cycle of third to 7 days of blood). The specific method of FSIGT: the subjects around the arms all keep a venous channel, maintain with saline, zero phase, in a minute on the side of the elbow intravenous injection of glucose 0.3 g / kg in the contralateral elbow vein collected 2, 3, 4, 5, 8, 10, 16, 19, 25 27, 30, 40, 50, 60, 80, 100, 120, 150, 180 minutes of blood glucose injection after 20 minutes, 30 seconds in the intravenous tolbutamide sodium (Orinase Diagnostic) 300mg (purchased from American Upjohn company). 3. laboratory testing methods and data processing Blood glucose was measured with glucose oxidase method, determination of insulin and C- peptide by radioimmunoassay, CV group were 4.7%, 3.4% and 3.9% batches of CV were 6.2%, 5.2% and 6%, the data were expressed as x + s, statistical processing method for t test. Two, the results 1. features of general data