泛昔洛韦片（Famvir）.docVIP

泛昔洛韦片（Famvir） Famciclovir Tablets (Famciclovir Tablets) The main ingredients of this product are. [traits] This product is made of white film, and the film is white after removing the film. [pharmacology and toxicology] The product has rapidly transformed into penciclovir compounds with antiviral activity, the latter of herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2) and varicella zoster virus (VZV) inhibition. In cell culture studies, the sequence of inhibitory actions on the following viruses was HSV-1, HSV-2, and VZV. The mechanism of action is as follows: in the cells infected with the virus, the thymidine kinase of the virus is phosphorylated with valaciclovir, which is then converted to three phosphate by cell kinase. In vitro studies have shown that three phosphate inhibits the activity of HSV-2 polymerase by competing with three guanosine phosphate, thereby selectively inhibiting the synthesis and replication of herpesvirus DNA. 2 years of rat and mouse carcinogenesis experiments confirmed that female rats received 600mg/kg/ days (equivalent to human recommended doses of 500mg or 125mg, 2 times a day, 1.5 to 9 times), and the incidence of breast cancer increased. Testicular toxicity was found in male rats, mice and dogs after taking this product. Female rats were given this product for 1000mg/kg/ days without reproductive toxicity. [pharmacokinetics] This product is orally rapidly absorbed and absorbed into the intestinal wall and then oxidized to active. 12 healthy male volunteers were treated with oral administration of 0.5g and intravenous injection of 0.4g, respectively. The results showed that the absolute bioavailability of this product was (77% + 8%). 124 healthy male volunteers received the goods after 0.5g, the peak concentration of penciclovir (Cmax) for (3.3 + 0.8) mg/L, peak time is (0.9 + 0.5) hours, the area under the plasma concentration time curve (AUC) for (8.6 + 1.9) Mg, h/L, blood elimination the half-life (t1/2b)