铁紊乱相关疾病的研究进展-PolyUIRA.PDF

2007 38 4 ·307 · ＊ 1, 2 1 2 1 1, 3, ■ 王　莉 　段相林 　王英泽 　常彦忠 　钱忠明 1 (, 0500 16; 2 3 , 050018; , ) 　铁作为一种必需的营养元素, 在哺乳动物体内的重要作用越来越为人们所重视。动物体内 存在着严 的铁代谢调节机制, 以确保体内铁始终处于正常生理水平。如果铁代谢失调、体内铁缺 乏或过负荷均会导致各种临床疾病。研究发现, 肝脏抗菌多肽(hepcidin)很可能是 一种控制小肠 铁吸收及调节体内铁稳态的关键物质, 是 一种极为重要的铁调节激素。本文综述了铁的生理作用、 铁缺乏引起的疾病(如:缺铁性贫血和儿童神经系统疾病 )和铁过负荷引起的疾病 (如:肝损伤、心 血管疾病、帕金森病和癌症等), 并对如何利用现代化技术手段在基因水平开展铁紊乱相关疾病的 治疗做了展望。 　缺铁性贫血;脑发育;铁缺乏;铁超载;肝脏抗菌多肽 　Q955 1, 2 1 ProgressoftheStudyonIronDisorderDiseases　 ANGLi, DUANXiang-Lin, ANGYing- 2 1 1, 3 1 Ze, CHANGYan-Zhong, QIANZhong-Ming (InstituteofNeurobiologyandNeuropharmacology, He- 2 beiNormalUniversity, Shijiazhuang050016, China; CollegeofBiosienceandBioengineering, HebeiUniversity 3 ofScienceandTechnology, Shijiazhuang0500 18, China; LaboratoryofIronMetabolism, DepartmentofAp- pliedBiologyandChemicalTechnology, TheHongKongPolytechnicUniversity, HongKong, China) Abstract　Themiportantfunctionofironasanecessarynutritionelementinmammalsismoreandmore recognizedbypeople.Thenormalphysiologicallevelofironisensuredbytherigidregulationmechanism ofironmetabolisminanmial.sVariousclinicaldiseasesareinducedbyirondisorde,rlikeirondeficiency andironoverloadinginthebody.ThecurrentstudyshowedthatHepcidinmaybeakeyfactortocontrol intestinalironabsorbingandregulatesironhomeostasi,sandmaybeanmiportantregulatinghormoneof-i ronmetabolism.Itwassummarizedinthispaperthatthephysiologicalfunction,s irondeficiencydisea-