二甲双胍及吡格列酮对2型糖尿病降糖疗效观察.docVIP

二甲双胍及吡格列酮对2型糖尿病降糖疗效观察 　［摘要］ 目的 观察二甲双胍和吡格列酮对2型糖尿病（T2DM）患者降糖的疗效。方法 80例血糖控制不良的T2DM患者在原治疗方案下，随机分为2组：二甲双胍组，给予盐酸二甲双胍500 mg，2次/d，和模拟吡格列酮片2片，1次/d；吡格列酮组，给予吡格列酮30 mg，1次/d，和模拟二甲双胍片1片，2次/d。各组疗程均为12周。结果 2组在治疗后空腹血糖（FPG）、餐后2 h血糖（2hPG）和糖化血红蛋白（HbA1C）较用药前明显降低。用药8周和12周时，吡格列酮组比二甲双胍组2hPG下降更明显。结论 二甲双胍和吡格列酮均能有效地降低FPG、2hPG和HbA1C，在用药8~12周时，吡格列酮在降低2hPG方面优于二甲双胍组。 ［关键词］ 2型糖尿病；二甲双胍；吡格列酮 Effect of meformin and pioglitazone on reducing blood sugar of type 2 diabetes ［Abstract］ Objective To investigate the effect of meformin and pioglitazone on reducing blood sugar of T2DM patients.Methods 80 T2DM patients with less controlled blood sugar were divided into two groups; the patients in meformin group were treated with meformin HCl 500 mg，twice a day，together with 2 tablets of the simulated pioglitazone，once a day; the patients in group pioglitazone were treated with pioglitazone 30 mg，once a day，together with 1 tablet of the simulated meformin，twice a day.The treatment of both groups was 12 weeks.Results After the treatment，the FPG，ZHPG and H6A1C in the second group were obviously lower than before the treatment.After 8 weeks and 12 weeks of receiving above treatments，ZHPG of the patients in pioglitazone group decreased more clearly than meformin group.Conclusion While meformin，pioglitazone were taken by the patients from 8 weeks to 12 weeks，the effect of pioglitazone group on decreasing ZHPG is superior to that of meformin group. ［Key words］ type 2 diabetes mellitus；meformin；pioglitazone 2型糖尿病（T2DM）的病理生理改变主要是胰岛素抵抗（IR）和胰岛素分泌不足。二甲双胍和吡格列酮均具有降低IR、改善糖代谢的作用［1］，本研究进行随机双盲对照试验，比较两种药物对T2DM患者的降糖效果。 1 资料与方法 1.1 一般资料 年龄35~65岁的T2DM患者80例，单纯饮食和运动治疗，FPG 7.8～14.0 mmol/L和（或）2hPG≥11.1 mmol/L者，未用胰岛素，无胃肠道、肝、肾、造血系统等主要脏器严重疾患。 1.2 方法 采用双盲双模拟随机对照研究的方法将80例受试者分为2组，每组40例。二甲双胍组早餐后口服盐酸二甲双胍500 mg和模拟吡格列酮片2片，晚餐后口服二甲双胍500 mg。吡格列酮组早餐后口服盐酸吡格列酮30 mg和模拟二甲双胍片1片，疗程均为12周。用药前及用药后2周、4周、8周、12周各随访1次，观察临床表现，测定FPG、2hPG、HbA1C。 1.3 统计学方法 用SPSS 12.0软件分析，计量资料以均数±标准差（x±s）表示，用t检验。分类资料用χ2检验。 2 结果 二甲双胍组中有3例失访，4例因不良反应退出；吡格列酮组有3例失访，5例因不良反应退出。这两组