头孢曲松钠预防腹股沟嵌顿疝无张力修补术后感染临床评价.docVIP

头孢曲松钠预防腹股沟嵌顿疝无张力修补术后感染临床评价 　【摘要】 目的：观察头孢曲松钠(Ceftriaxone sodinm)用于腹股沟嵌顿疝无张力修补术后感染的临床效果。方法：选择同期住院施行嵌顿疝无张力修补术的病例。随机分成试验组和对照组,试验组:术前30 min，术后1 h静脉滴注头孢曲松钠1.0 g~2.0 g,术后1次/d，1.0 g/次~2.0 g/次,疗程3 d~5 d。对照组:术前30 min,术后1 h,静脉滴注罗氏芬1.0 g~2.0 g,术后1次/d,1.0 g/次~2.0 g/次,疗程3 d~5 d。结果：头孢曲松钠与罗氏芬临床总有效率、细菌清除率及不良反应率等方面差异无显著性。结论：头孢曲松钠能有效预防嵌顿疝无张力修补术后感染,无明显副作用。 【关键词】 头孢曲松钠；罗氏芬；预防；术后感染；疝修补术 　　Evaluate the Clinical Effect of Ceftriaxone Sodium in Prevention of Infection after Tensionfree herniorrhaphy Incarcerted Inguinal Hernia Abstract: Objective To evaluate the clinical effect of ceftriaxone sodium in prevention of infection after tensionfreeherniorrhaphy incarcerted inguinal hernia. Methods The patients who underwent tensionfreeherniorrhaphy incarcerted inguinal hernia in the same period were elected and divided into trial group and control group randomly.Trial group: ceftriaxone sodium was given by intravenousdripat preoperative 30 min,postoperative 1 h and once a day after operation for 3 days~5 days;control group:1.0 g~2.0 g rocephin was given by intravenousdripat preoperative 30 min,posloperalive 1 h and once a day after operation for 3 days~5 days. Results There was no significant difference between ceftriaxone sodium group and rocephin group in total clinical effective rale,baclerial clearance rale,occurrence rate of adverse effect and so on. Conclusion Ceflriaxone sodium can be applied to prevent postoperative infection of tensionfreeherniorrhaphy incarcerted inguinal hernia. Key words: Ceftriaxone sodium; Rocephin; Prevention; Postoperative infection; Herniorrhaphy 收集2004年９月至2006年２月期间，应用头孢曲松钠预防嵌顿疝无张力修补术后感染病例，并与进口罗氏芬同期对比观察，现报告如下。 　　１ 资料与方法 　　１.１ 临床资料 　　选择２００4年９月至2006年２月在我院施行嵌顿疝无张力松解术的患者38例，患者均无肠管破裂,无肠内容物直接污染局部组织,术中观察肠管均无绞窄征象，疝囊及周围组织无蜂窝织炎及严重水肿。年龄55岁～78岁，男32例，女6例。头孢曲松钠组（试验组）与罗氏芬组（对照组）各19例，其中两组均各有2例患者合并有2型糖尿病。两组患者治疗前２ d内均未接受抗生素治疗，两组在年龄、性别、体重、病情、用药疗程等方面差异均无显著性。 　　1.2 方法 　　1.2.1 给药方法 　　试验组:术前30 min，术后1 h静脉滴注头孢曲松钠（海南海灵药业有限公司生产）1.0 g~2.0 g,术后1次/d，1.0 g/次~2.0 g/次,疗程3 d~5 d。对照组: