探析血脂测定在精神病患者非醇性脂肪性肝炎临床价值.docVIP

探析血脂测定在精神病患者非醇性脂肪性肝炎临床价值 　【关键词】 ,,血脂；非醇性脂肪性肝炎；精神病患者 　　［摘要］ 目的 探讨血脂测定对诊断住院精神病患者非醇性脂肪性肝炎（NASH）的临床价值。方法 对119例住院精神病患者采用自动化分析仪测定血脂浓度及腹部B超检查。结果 住院精神病患者NASH发病率18.49%，女性患者的NASH发病率高于男性患者，NASH组的CHO、TG显著高于对照组（P＜0.05），男性NASH组的CHO、TG显著高于对照组（P＜0.05）；NASH组与对照组的高脂血症发生率比较可见：单纯高TG血症或合并高CHO血症的发生率NASH组显著高于对照组（P＜0.005）。结论 高TG血症或合并高CHO血症易引起NASH，而单纯高CHO血症并非是NASH的血脂表现特点，联合腹部B超可提高诊断NASH的敏感性和准确性。 ［关键词］ 血脂；非醇性脂肪性肝炎；精神病患者 Value of the blood lipid determination on schizophrenia inpatients with nonalcoholic steatohepatitis ［Abstract］ Objective To assess the value of the blood lipid determination on schizophrenia with nonalcoholic steaohepatitis（NASH）.Methods 119 schizophrenia inpatients had a abdominal brightness mode ultrasonic examinatic.Their blood lipid concentration were detected by automatic device.Results The morbidity of schizophrenia inpatients with NASH is 18.49%,female’s was higher than male’s.Cholesterol and triglyceride of NASH patients was significantly higher than the control group’（P＜0.05）.Cholesterol and triglyceride of NASH male patients was significantly higher than the control group（P＜0.05）.It can found than the morbitity of purely hypertrigiyceride or with hypercholesterolemia NASH patients was significantly higher than the control group 119 schizophrenia inpatients were randomly divided into two groups.Conclusion NASH is easily caused by hypertriglyceride or hypercholesterolemia,but purely hypercholesterolemia is not the blood lipid characteristic of NASH patients.It can improved the sensibitity and accuracy of NASH diagnosis by blood lipid determination and abdominal brightness mode ultrasonic examination. ［Key words］ blood-lipid;nonalcoholic steatohepatic;psychotic 长期服用抗精神病药的精神病患者,常出现脂类代谢方面的障碍和程度不等的肝脏炎症,如体重增加、高脂血症，在肝脏多见的是腹胀、肝区疼痛，SGPT中度升高；而肥胖、服用化学药物等是非醇性脂肪性肝炎（NASH）的重要病因。本文通过测定患者的血脂浓度及腹部B超检查，以探讨诊断NASH的临床价值，有关NASH的临床研究已日益受到重视。 1 对象与方法 1.1 研究对象 患者为我院及北京回龙观医院2个病区的住院精神病患者，服用抗精神病药物治疗，病程在1年以上，排除酗酒、妊娠、半乳糖血症、糖原、类脂累积病和静脉营养者，入组者共119例。 1.2 方法 采用自动化分析仪测定血清血脂浓度，高脂血症的诊断标准：甘油三酯（TG