甘利欣联合优思弗治疗慢性乙型肝炎疗效观察.docVIP

甘利欣联合优思弗治疗慢性乙型肝炎疗效观察 　 作者：谭小芸， 刘兴峰， 陈星浩 【关键词】 慢性乙型肝炎;,,甘利欣胶囊;,,优思弗胶囊;,,疗效 　　摘要：目的：观察优思弗联合甘利欣胶囊治疗慢性乙型肝炎的疗效。方法:87例慢性乙型肝炎患者均为抗病毒治疗失败或肝功能长期异常者,随机分为治疗组(47例)和对照组(40例),分别给予甘利欣胶囊联合优思弗胶囊和复方甘草酸苷+维生素C治疗,疗程均为8wk。结果:治疗组在肝功能、免疫功能改善方面优于对照组(Plt;0.05);治疗组与对照组总有效率分别为89.4%、67.5%(Plt;0.01)。结论:甘利欣联合优思弗治疗抗病毒失败或肝功能长期异常者有效。 　　关键词： 慢性乙型肝炎; 甘利欣胶囊; 优思弗胶囊; 疗效 　　Observing the Effect of Glycyrrhizinate Comownd Ursodeoxycholi acid on Treating Chronic Hepatits B 　　Abstract: Objective: To observe the therapeutic effect of compound glycyrrhizin combining ursodeoxy-cholic acid in the treatment of chronic hepatitis B.Method: 87 patients with chronic hepatitis B were enrolled to,on whom, the anti-viral therapy proved to be ineffective and who suffered a long- term abnormal liver functions, of the total ,47 were randomly assignesd to receive compound glycyrrhizin plus ursodeoxycholic acid(treatment,group), and 40 to receive compound glycyrrhizin plus vitamin C(control group). Course of treatment for both groups was 8 weeks. Result: As compared with the control group, the liver function and immune function for the treatment group had a better amelioration(Plt;0.05) );the total effective group, the liver function and immune control group were 89.4% and 67.5%(Plt;0.01), respectively. Conclusion: Compound glycyrrhizin plus ursodeoxycholi acid is effective in treatment of chronic hepatitis B cases when anti-viral therapy is ineffective and whose liver function are abnormal for a long time. 　　Key words: Chronic hepatitis B; Glycyrrhizinate capsules; Ursodeoxycholic acid capsules; Therapeutic effect 　　目前,我国乙型肝炎病毒(HBV)感染者达1.2亿,其中50～75%的慢性感染者有活动的病毒复制和肝脏炎症改变,慢性乙型肝炎的发生机制尚不明确,故迄今无统一疗法,尽管干扰素或拉米夫定治疗慢性乙型肝炎有效,但受多种因素影响,不能得到广泛应用。本研究中,笔者应用甘利欣胶囊联合优思弗治疗慢性乙型肝炎,取得较满意的效果,现报道如下。 　　1 资料与方法 　　1.1 病例选择：来我院就诊的慢性乙型肝炎患者共计87例,均为抗病毒治疗失败或无抗病毒治疗指征而肝功能长期异常者,诊断符合2000年9月“第10次全国病毒性肝炎会议”修订的诊断标准［1］。随机分为治疗组和对照组,2组基本情况详见表1。 　　表1 两组病例基本情况比较(略) 　　由表1可见,2组在性别、年龄、分型方面无显著性差异(Pgt;0.05),具有可比性 　　1.2 治疗方法：治疗组:口服甘利欣胶囊(江苏正大天晴药业股份有限公司50mg/粒)150mg/次,3次/d;优思弗