生脉胶囊治疗慢性充血性心力衰竭临床疗效TOPSIS法综合评价.docVIP

生脉胶囊治疗慢性充血性心力衰竭临床疗效TOPSIS法综合评价 　【摘要】 　　目的 中医药临床研究的质量和水平较低，急需科学、系统而综合的临床评价方法来体现中医在防病治病方面有其独到的疗效优势。方法 应用TOPSIS理想点多属性综合评价的方法，对生脉胶囊治疗慢性充血性心力衰竭的临床疗效进行多指标（多属性）临床疗效综合评价，通过本试验研究探讨并初步建立一套中药（新药）临床试验研究的临床疗效综合评价方法和技术路线。结果 排序结果表明治疗组的临床疗效明显优于安慰剂组，且治疗组与正理想解和负理想解的相对接近程度Ci值为0.9534，已然非常接近1。结论 可以建立合理的方法和模型来综合评价中药（新药）的临床疗效并为其疗效等级排序。 【关键词】 生脉胶囊　临床疗效　综合评价　TOPSIS理想点法 　【Abstract】 Objective The clinical investigative quantity in Chinese medicine is lower with the level, Chinese medicine in the aspects of defending disease curing illness containing especially original advantage, the demonstration of these advantagese needs the clinical evaluation method of science, system urgently.Methods Applying the AHP（ analytic hierarchy process）―the one method of the synthetical evaluation, pass “Double－blind，randomized，placebo－controlled clinical trail on chronic congestive heart failure （CHF） with Shengmai capsule treatment, which add to the base of normal treatment” to evaluate and investigate the clinical curative effect in this clinical trial ，to establish and investigate the keys and the technique norm about clinical curative effect in clinical trial in a set of Chinese herbal medicines（ new medicine）.Results The treatment group of the clinical curative effect is obvious better than placebo group, and treatment group near to degree Ci value is 0.9534 has very near to 1.Conclusion Elucidation Shengmai capsule treatment the CHF near to very much the justice the ideal project,can establish the reasonable method to evaluate the Chinese herbal medicine（ new medicine） with stable model and preface the clinical curative effect for its curative effect grade row. 【Key words】 Shengmai capsule;clinical curative effect;synthetical evaluation;TOPSIS method 中医药临床研究的质量和水平较低、诊断和疗效评价标准不为人们接受已成为制约我国中医药产业持续发展和中药以治疗药物的身份进入国际市场的“瓶颈”之一［1］。 中医在防病治病方面有其独到的疗效优势，这些优势的展示亟须科学、系统而综合的临床评价方法来体现。祖国医学发扬光大并与世界医学接轨，需要注入新鲜血液，而多学科的融合、先进有效的方法学的研究运用当是一个重要的阶梯。选择性地运用一种或多种综合评价方法，通过数理统计的计算，从多侧面，用多指标立体评价中药（新药）对治疗某种病证的有效性和安全性，应是行之有效的，而且是