胰岛素样生长因子Ⅰ、脐血瘦素及胰岛素及胎儿宫内发育迟缓相关.docVIP

胰岛素样生长因子Ⅰ、脐血瘦素及胰岛素及胎儿宫内发育迟缓相关 　【关键词】 胰岛素样生长因子-Ⅰ；,,胰岛素；,,瘦素；,,胎儿宫内发 　　摘要：目的：探讨胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、脐血瘦素（Leptin）及胰岛素(Ins)与胎儿宫内发育迟缓(IUGR)的相关关系。方法：应用放射免疫分析法和酶联免疫吸附试验，分别测定46例IUGR患儿、孕妇(IUGR组)血清IGF-Ⅰ和脐血瘦素、Ins水平，同期住院的正常晚期妊娠妇女52例(正常妊娠组)作为对照。结果：①IUGR组孕妇血清IGF-Ⅰ为（112.58±21.23）ug/L，低于正常妊娠组的（209.13±25.98）ug/L，两者比较，有显著性差异(Plt;0.01)；IUGR组脐血清IGF-Ⅰ为(15.68±6.76) ug/L，低于正常妊娠组的(45.19±11.25) ug/L，两者比较，有极显著性差异(P lt;0.001)。②IUGR儿脐血瘦素为(5.35±3.02)ng/ml，低于正常妊娠组的(8.97±4.34) ng/ml，两者比较，有显著性差异(P lt;0.05)。③IUGR儿脐血Ins为(8.98±5.60)mU/L，低于正常妊娠组的(16.19±8.15) mU/L，两者比较，有显著性差异(P lt;0.05)。结论：IGF-Ⅰ、Ins及瘦素可能参与IUGR的病理生理过程。 　　关键词： 胰岛素样生长因子-Ⅰ； 胰岛素； 瘦素； 胎儿宫内发育迟缓 　　The Correlationship of Insulin-like Growth Factor、Leptin of Omphaloblood、Insulin and Intrauterine Growth Retardation of Fetus 　　Abstract : Objective： To explore the correlationship of IGF-Ⅰ、Leptin of omphaloblood、insulin and intrauterine growth retardation of fetus. Method： Assayed the level of IGF-Ⅰ、Leptin of omphaloblood、insulin in blood serum of 46 cases of IUGR children and their mothers by radio-immunity analysis mathod and enzyme linked immunosorbent assay. And 52 cases of normal late pregnancy women in the hospital at the same time ( nomal pregnancy group) were contrast group. Result： ①IGF-Ⅰin gravida blood serum of IUGR group was （112.58±21.23）ug/L , which was lower than （209.13±25.98）ug/L in nomal pregnancy group. There was significant difference in the two groups (Plt;0.01); IGF-Ⅰin omphaloblood serum of IUGR group was (15.68±6.76) ug/L, which was lower than (45.19±11.25) ug/L in nomal pregnancy group. There was significant difference between the two groups (Plt;0.001). ②Leptin of omphaloblood in IUGR group was (5.35±3.02)ng/ml, which was lower than (8.97±4.34) ng/ml in normal pregnancy group. There was significant difference in the two groups (Plt;0.05).③Insulin of omphaloblood in IUGR group was (8.98±5.60)mU/L, which was lower than (16.19±8.15) mU/L in normal pregnancy group. There was significant difference in the two groups (Plt;0.05). Con