贯叶连翘提取物治疗抑郁症临床疗效浅谈.docVIP

贯叶连翘提取物治疗抑郁症临床疗效浅谈 　关键词：贯叶连翘 【摘要】 目的 比较贯叶连翘提取物和阿米替林片治疗抑郁症的疗效及不良反应。方法 采用开放性对照研究方法，将100例抑郁症患者随机分成2组，治疗组50例，对照组50例。治疗组口服贯叶连翘提取物1.8～2.7g，分3次服；对照组给予阿米替林50～250mg ，分2次服。以汉密顿抑郁量表（HAMD）及副反应观察量表（TESS）分别观察二组治疗抑郁症的疗效及不良反应。二组治疗时间均为6周。结果 治疗组有效率为83.7%，对照组有效率为85.4%，Radit分析，P＞0.05，药物不良反应发生率对照组多于治疗组。结论 贯叶连翘提取物是一个疗效确切且耐受性好的抗抑郁药物。 【关键词】 贯叶连翘；郁福来胶囊；阿米替林；抑郁症 Pilot study on clinic effects of the the ethanol extracts of Hypericum perforatum L. in treatment of depression 【Abstract】 Objective To compare the efficacy， adverse effects and onset of the ethanol extracts of Hypericum perforatum L. and amitriptyline. Methods 100 patients who met the CCMD-Ⅲ criteria for depression were allocated 50 cases into treatment group and the other into control group at random， treated with either the ethanol extracts of Hypericum perforatum L. (0.9g， tid ) and amitriptyline(150mg， bid )for a period of 6 weeks in a opened， placebo controlled trial. HAMD and TESS were adopted to evaluated the therapeutic respones and adverse effects. Results The scores on HAMD had not shown significant difference between two groups. The efficiency ratio of treatment group and control group were 83.7%and 85.4%， respectively. The adverse effects of treatment group were less and mild compared with group. The onset of action were similar between these two medications. Conclution The ethanol extracts of Hypericum perforatum L. is a effective， well tolerative antidepressant. 【Key words】 hypericum perforatum L；yufulai capsules； amitriptyline； depression 贯叶连翘（Hypericum perforatum L.）为藤黄科金丝桃属植物，在西方国家又名“St.Johns wort” 。传统中医［1］认为贯叶连翘具有清心明目、调经活血、止血生肌、解毒消炎的功效。现代药理研究表明：贯叶连翘具有抗抑郁、抗病毒、抗菌、镇痛等作用［2］ 。近年来，欧、美等国家将其应用在抑郁症治疗症治疗方面，取得了很好的疗效，其浸膏制剂已在德国上市，并占德国抗中、轻度抑郁症药物市场的将近50%［3］，进一步药理研究表明［4］：贯叶连翘的抗抑郁作用一是通过抑制5-羟色胺的回收，二是通过抑制单胺氧化酶，三是通过作用于多巴胺及去甲肾上腺素来实现的，因此它的抗抑郁作用是各种成分综合作用的结果。在强迫游泳试验中［5］提示贯叶连翘具有抗抑郁作用。本研究通过临床对照试验，对贯叶连翘提取物(暂名：郁福来胶囊)的治疗抑郁症的疗效和安全性及耐受性作出初步评价。 1 材料与方法 1.1 研究对象 选择符合中国精神疾病分类与诊断标准第三版(CCMD-Ⅲ)抑郁症发作诊断标准的住院患者。无躯体及脑器质性疾病，Hamilton