连柏液防治放射性皮肤损伤临床分析.docVIP

连柏液防治放射性皮肤损伤临床分析 　 作者：马红兵，张晓智，白明华，王西京 【关键词】 黄连；黄柏；放射性皮炎 　　Clinical effect of lianbai liquid in the prevention and treatment of irradiationinduced dermal injury 　　【Abstract】 AIM: To observe the clinical effect of lianbai liquid in the prevention and treatment of irradiationinduced acute dermal injury. METHODS: The carcinoma patients(n=126) who had to accept radiotherapy from May, 2000 to December,2005, were randomized into 2 groups :prevention group (n=75 ) was given lianbai liquid since the 1st radiotherapy session ,and control group 1 (n=51) was given only general and health education program without lianbai liquid application. Other 92 cases of 3grade radiationinduced dermatitis were randomly divided into 2 groups (n=54 in treatment group, n=38 in control group 2). The evaluation of radiationinduced acute dermatitis was done according to CTC.V2.0 proposed by NCI. RESULTS: Skin reaction rate and grade in the prevention group(32.0%) was obviously lower than that of the control group 1 (92.2%) (u=6.769, Plt;0.01). The mild radiation reaction(1+2 grade)rate in the prevention group(28.0%) was obviously lower than that of the control group 1 (70.6%), with significant difference between the 2 groups (χ2 =22.226, Plt;0.01). The effective rate of 3 grade acute radiationinduced dermatitis in treatment group was 92.6%(50/54)，better than that in control group 2 (65.9%, 25/38)(χ2=6.018, P=0.024). The healing time of 3 grade radiationinduced dermatitis was (11.07±2.21)d in the treatment groups and was obviously shorter than that of the control group 2 (18.08±1.76)d (u=16.932， Plt;0.01). CONCLUSION: Lianbai liquid can effectively prevent irradiationinduced acute dermal injury and treat the 3 grade radiationinduced acute skin injury. The application of lianbai liquid is safe, economic and convenient. It can alleviate the patients suffering and improve their quality of life. 　　【Keywords】　coptidis rhizoma; cortex phellodendri; radiodermatitis 　　【摘要】　目的：　观察连柏液在预防和治疗急性放射性皮肤损伤中的作用. 方法