注射用硫酸卷曲霉素（Capreomycin Sulfate for Injection）.docVIP

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注射用硫酸卷曲霉素（Capreomycin Sulfate for Injection）.doc

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注射用硫酸卷曲霉素（Capreomycin Sulfate for Injection）

注射用硫酸卷曲霉素（Capreomycin Sulfate for Injection） Capreomycin Sulfate for Injection Name used before English name CAPREOMYCIN, SULFATE, FOR, INJECTION Pinyin name ZHUSHEYONG, LIUSUAN, JUANQUMEISU Drug category other Properties of this product are white or white powder. Pharmacology and toxicology, which are peptide complexes, have inhibitory effects on Mycobacterium tuberculosis, and the mechanism is not clear. It may be related to the inhibition of bacterial protein synthesis. Bacteria are susceptible to drug resistance when used alone. There is incomplete cross resistance between this product and kanamycin and kanamycin. Pharmacokinetics. This product is not taken orally and must be injected. This product is very high in the urine, but also through the placenta, but it can not penetrate the cerebrospinal fluid. The peak concentration of serum reached 1~2 hours after intramuscular injection of 1G (Cmax), which ranged from 20 to 40mg/L. The blood elimination half-life (t1/2 beta) was 3~6 hours. This product is mainly excreted by glomerular filtration, excreted in urine within 12 hours, 50% to 60% of the dosage, and a small amount can be excreted by bile. In patients with renal impairment, the clearing half-life is prolonged, and the serum can be accumulated with aspergillus. To second-line drugs for pulmonary tuberculosis disease, the first-line antituberculosis drugs (such as streptomycin, isoniazid, rifampicin and ethambutol) treatment failure, or the drug in one or several kinds of toxic or bacterial resistance, this product can be used as one of the drugs combined with. Usage, dosage, when used, add Sodium Chloride Injection to dissolve. Deep intramuscular injection, adults 1g, for 60~120 days, and then 2~3 times a week, each time 1g; now advocated every time 0.75g, 1 times a day. Adverse reactions 1.. This product has significant renal toxicity, including creatinine, urea nitrogen, creatinine clearance, proteinuria, tubular urine, and renal function and urinalysis d