浅谈氨基糖苷类抗生素不良反应和防治策略（Adverse reactions and control strategies of aminoglycoside antibiotics）.docVIP

浅谈氨基糖苷类抗生素不良反应和防治策略（Adverse reactions and control strategies of aminoglycoside antibiotics） Adverse reactions and control strategies of aminoglycoside antibiotics Date: 07, 10 With the widespread use of antibiotics, drug-resistant strains have become a common cause of clinical infections. Some experts have proposed antibiotic cycling (rotation) medication strategies and strategic change dressings. Aminoglycoside antibiotics are susceptible to many drug-resistant strains [1]. However, the narrow range of therapeutic concentrations of these drugs and the more common adverse reactions, some of which are irreversible toxicities, are the major reasons for their widespread use in the clinic. For the rational use of the drug, this article focuses on the following aminoglycoside antibiotics adverse reactions and prevention and treatment strategies. Classification and metabolic processes of 1 aminoglycoside antibiotics Classified according to the source of the drug can be summarized as follows: (1) the extracts from the culture filtrate of Streptomyces are: streptomycin, neomycin, kanamycin and so on. (2) Micromonospora culture filtrate extract Abstract: such as gentamicin, sisomycin magnitude. (3) summary of semisynthetic antibiotics such as Amikacin and netilmicin. Aminoglycosides are depended on the concentration of fungicide, is close to its therapeutic and toxic doses, the drug is alkaline, soluble in water, gastrointestinal absorption, intramuscular injection is absorbed quickly and completely, 30 ~ 90min peak concentration. The intravenous drug concentration with different therapeutic doses, general intravenous infusion of 20 ~ 30min concentration and plasma concentration of intramuscular injection at the same. The binding rate of aminoglycosides and plasma proteins is very low, mainly distributed in the extracellular fluid, the polarity is strong, it is difficult to penetrate the biofilm, and the content of the cells in human tissue is very low. But because of the un