乙肝疫苗行业分析报告 - 仪器信息网.DOCVIP

乙肝疫苗行业分析 报告 区春雄 2006.10 说明 本报告所用资料均来源于网上公开资料，不能保证其正确性和最新性，在此基础上所作分析可能存在谬误，仅供考！ 目录 概论　生物医药行业特征生物医药行业特征公司简介公司报告期财务数据同比发生重大变动公司现金流量表相关数据生物医药行业特征生物医药行业特征specific immunotherapy in chronic hepatitis B[J].J Hepatol,2001,34:917-921. [10] Senturk H,Tabak F,Akdogan M,et al.Therapeutic vaccina-tion in chronic hepatitis B[J].J Gastroenterol Hepatol,2002,17:72-76. [11] Jung MC,Gruner N,Zachoval R,et al.Immunological monito-ring during therapeutic vaccination as a prerequisite for the de-sign of new effective therapies:induction of a vaccine-specificCD4+T-cell proliferative response in chronic hepatitis B carri-ers[J].Vaccine,2002,20:3598-3612. [12] Dikici B,Bosnak M,Ucmak H,et al.Failure of therapeutic vaccination using hepatitis B surface antigen vaccine in the immunotolerant phase of children with chronic hepatitis B infection [J].J Gastroenterol Hepatol,2003,18:218-222. [13] Ren F,Hino K,Yamaguchi Y,et al.Cytokine-dependent antiviral role of CD4-positive T cells in therapeutic vaccination against chronic hepatitis B viral infection[J].J Med Virol,2003, 71:376-384. [14] Yalcin K,Danis R,Degertekin H,et al.The lack of effect of therapeutic vaccination with a pre-S2/S HBV vaccine in the immune tolerant phase of chronic HBV infection[J].J Clin Gas-troenterol,2003,37:330-335. [15] Yalcin K,Acar M,Degertekin H.Specific hepatitis B vaccinetherapy in inactive HBsAg carriers:a randomized controlled trial[J].Infection,2003,31:221-225. [16] Chen M,Li YG,Zhang DZ,et al.Therapeutic effect of autologous dendritic cell vaccine on patients with chronic hepatitis B:A clinical study[J]. World J Gastroenterol, 2005, 11: [17] Mancini-Bourgine M,Fontaine H,Scott-Algara D,et al.Induction or expansion of T-cell responses by a hepatitis B DNA vaccine administered to chronic HBV carriers[J]. Hepatology, 2004,40:874-882. [18]刘顺爱,徐道振,张剑平,等.治疗性乙型肝炎疫苗的免疫效应 [J].中华肝脏病杂志,2006,14:89-92. 表4 在研的治疗性乙肝疫苗 三　几种乙型肝炎疫苗综述 1 血源乙型肝炎疫苗 血源乙肝疫苗是用从慢性HBV感染者血浆中提纯HBsAg、经多种手段联合灭活处理后吸附铝佐剂制备的。美国默沙东制药公司最早于1981年获得血源乙肝疫苗