RLPO改性亲水性SIS热熔压敏胶基质配比研究-天津中草药杂志社.PDFVIP

·748 · 中草药 Chinese Traditional and Herbal Drugs 第47 卷 第5 期 2016 年3 月 RLPO 改性亲水性 SIS 热熔压敏胶基质配比研究 赵 旭，汪 坤 河南省中医院，河南 郑州 450002 摘 要：目的 优选适宜亲水性物质释放的热熔压敏胶基质的配比。方法 采用正交试验法，以胶体的黏性、亲水性药物的 释放度为指标，以C5 石油树脂、以苯乙烯-异戊二烯-苯乙烯（SIS ）、丙烯酸乙酯- 甲基丙烯酸甲酯- 甲基丙烯酸氯化三甲胺基 乙酯共聚物（RLPO ）、液体石蜡、邻苯二甲酸二辛酯（DOP ）、聚乙二醇400 （PEG 400 ）、抗氧化剂1010 为材料，筛选热熔 压敏胶基质的配方。结果 最佳基质配比为SIS-C 石油树脂-RLPO-液体石蜡-PEG 400-DOP-抗氧化剂1010 为3 ∶4 ∶6 ∶6 ∶ 5 5 ∶1 ∶0.1，所制得的热熔压敏胶黏性适宜，对亲水性药物释放度高。结论 本研究制备的热熔压敏胶是制备亲水性药物经 皮给药贴剂的良好材料。 关键词：热熔压敏胶；亲水性；释放度；丙烯酸乙酯- 甲基丙烯酸甲酯- 甲基丙烯酸氯化三甲胺基乙酯共聚物（RLPO ）；C5 石油树脂；苯乙烯-异戊二烯-苯乙烯（SIS ）；液体石蜡；邻苯二甲酸二辛酯（DOP ）；聚乙二醇 400 （PEG 400 ）；抗氧化剂 1010；经皮给药；贴剂 中图分类号：R283.6 文献标志码：A 文章编号：0253 - 2670(2016)05 - 0748 - 04 DOI: 10.7501/j.issn.0253-2670.2016.05.010 Study on matrix proportion of hydrophilic SIS hot melt pressure sensitive adhesive suit modified by RLPO ZHAO Xu, WANG Kun Henan Province Hospital of TCM, Zhengzhou 450002, China Abstract: Objective To optimize the matrix proportion of SIS hot melt pressure sensitive adhesive suit for hydrophilic material releasing. Methods By orthogonal test method, taking adhesiveness and hydrophilic drug release rate as factors, and C5 petroleum resin hydrogenate, lanoline styrene-isoprene-styrene (SIS) triblock copolymer, ethyl acrylate-methyl methacrylate-trimethylamino (RLPO), liquid paraffin, dibutyl phthalate (DOP), polyethylene glycol (PEG) 400, and Antioxidant 1010 as materials, the matrix proportion was optimized. Results The optimized formulation was as follows: SIS-C5 petroleum resin hydrogenate-SIS-RLPO-DOP-PEG 400-Antioxidant 1010 was 3 ∶4 ∶6 ∶6 ∶5 ∶1 ∶0.1. The adhesiveness was proper and shows more release rate for hydrophilic material. Conclusion The SIS hot melt pressure sensitive adhesive shows good property and is suitable to prepare transdermal